Apo A-I and apo E concentrations in cerebrospinal fluids of patients with acute meningitis

Hua Song, Mitsuru Seishima, Kuniaki Saito, Satoshi Maeda, Masao Takemura, Akio Noma, Akira Kondo, Mitsuhisa Manabe, Katsuya Urakami, Kenji Nakashima

研究成果: Article査読

12 被引用数 (Scopus)


It has been demonstrated that apolipoproteins found in cerebrospinal fluid (CSF) play an important role in lipid metabolism in the central nervous system (CNS). Previously we reported that CSF apo A-I levels increased with the severity of neurological damage in poliovirus-infected macaques. In the present study, apo A-I was quantitatively analysed in CSF from patients with or without neurological diseases. In controls, CSF apo A-I level was significantly higher in males; 3.83 (0.40) mg/L, mean (SEM) (n = 19) compared with females, 2.42 (0.26) mg/L (n = 23, P < 0.05). CSF apo A-I concentrations in patients with acute meningitis increased at the active stage, 7.74 (1.78) mg/L (n = 10), but returned to basal concentrations at the convalescent stage 2.72 (0.38) mg/L (n = 10), while the CSF apo A-I level in patients with other neurological diseases remained in the same range as in controls. By contrast, CSF apo E was consistently elevated at either stage of acute meningitis. Furthermore, it was found that the levels of CSF apo A-I, but not of apo E, correlated positively with CSF albumin concentrations. These findings suggest that the CSF apo A-I and apo E have different origins and may play different roles in the lipoprotein metabolism in CNS.

ジャーナルAnnals of Clinical Biochemistry
出版ステータスPublished - 05-1998

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

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