Apolipoprotein a2 isoforms in relation to the risk of myocardial infarction: A nested case-control analysis in the jphc study

Tomomi Kihara, Kazumasa Yamagishi, Kazufumi Honda, Ai Ikeda, Hiroshi Yatsuya, Isao Saito, Yoshihiro Kokubo, Taiki Yamaji, Taichi Shimazu, Norie Sawada, Motoki Iwasaki, Hiroyasu Iso, Shoichiro Tsugane

研究成果: ジャーナルへの寄稿学術論文査読

2 被引用数 (Scopus)

抄録

Aim: The fact that low concentrations of high-density lipoprotein cholesterol are associated with the risk of car-diovascular disease is well known, but high-density lipoprotein metabolism has not been fully understood. Apoli-poprotein A2 (ApoA2) is the second-most dominant apolipoprotein of high-density lipoprotein. We tested the hypothesis that ApoA2 isoforms are inversely associated with myocardial infarction. Methods: We measured the plasma levels of three ApoA2 isoforms (ApoA2-ATQ/ATQ, ApoA2-ATQ/AT, ApoA2-AT/AT) in nested case-control study samples of 1:2 from the Japan Public Health-Center-based Study (JPHC Study): 106 myocardial infarction incidence cases and 212 controls. Results: ApoA2-AT/AT was inversely associated with risk of myocardial infarction, in a matched model (OR, 2.78; 95% Cl, 1.26-6.09 for lowest compared with the highest quartile), but its association was attenuated after adjustment for smoking only (OR=2.13; 95% Cl, 0.91-4.97) or drinking only (OR=2.11; 0.91-4.89), and the multivariable OR was 1.20 (95% Cl, 0.41-3.57). Neither ApoA2-ATQ/ATQ nor ApoA2-ATQ/AT was associ-ated with the risk of myocardial infarction. Conclusions Our nested case-control study did not show a significant association of ApoA2 isoforms with a risk of myocardial infarction.

本文言語英語
ページ(範囲)483-490
ページ数8
ジャーナルJournal of atherosclerosis and thrombosis
28
5
DOI
出版ステータス出版済み - 2021

All Science Journal Classification (ASJC) codes

  • 内科学
  • 循環器および心血管医学
  • 生化学、医学

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