TY - JOUR
T1 - Association analysis between schizophrenia and the AP-3 complex genes
AU - Hashimoto, Ryota
AU - Ohi, Kazutaka
AU - Okada, Takeya
AU - Yasuda, Yuka
AU - Yamamori, Hidenaga
AU - Hori, Hiroaki
AU - Hikita, Takao
AU - Taya, Shinichiro
AU - Saitoh, Osamu
AU - Kosuga, Asako
AU - Tatsumi, Masahiko
AU - Kamijima, Kunitoshi
AU - Kaibuchi, Kozo
AU - Takeda, Masatoshi
AU - Kunugi, Hiroshi
N1 - Funding Information:
This work was supported in part by Grants-in-Aid from the Japanese Ministry of Health, Labor and Welfare (H18-kokoro-005, H19-kokoro-002).
PY - 2009/9
Y1 - 2009/9
N2 - A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia (χ2 = 6.33, P = 0.012, odds ratio = 0.80) was no longer positive after correction for multiple testing (corrected P = 0.192). The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia in this population.
AB - A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia (χ2 = 6.33, P = 0.012, odds ratio = 0.80) was no longer positive after correction for multiple testing (corrected P = 0.192). The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia in this population.
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U2 - 10.1016/j.neures.2009.05.008
DO - 10.1016/j.neures.2009.05.008
M3 - Article
C2 - 19481122
AN - SCOPUS:67650433833
SN - 0168-0102
VL - 65
SP - 113
EP - 115
JO - Neuroscience Research
JF - Neuroscience Research
IS - 1
ER -