Association analysis between schizophrenia and the AP-3 complex genes

Ryota Hashimoto, Kazutaka Ohi, Takeya Okada, Yuka Yasuda, Hidenaga Yamamori, Hiroaki Hori, Takao Hikita, Shinichiro Taya, Osamu Saitoh, Asako Kosuga, Masahiko Tatsumi, Kunitoshi Kamijima, Kozo Kaibuchi, Masatoshi Takeda, Hiroshi Kunugi

研究成果: Article査読

6 被引用数 (Scopus)

抄録

A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia (χ2 = 6.33, P = 0.012, odds ratio = 0.80) was no longer positive after correction for multiple testing (corrected P = 0.192). The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia in this population.

本文言語English
ページ(範囲)113-115
ページ数3
ジャーナルNeuroscience Research
65
1
DOI
出版ステータスPublished - 09-2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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