Association analysis between schizophrenia and the AP-3 complex genes

Ryota Hashimoto; Kazutaka Ohi; Takeya Okada; Yuka Yasuda; Hidenaga Yamamori; Hiroaki Hori; Takao Hikita; Shinichiro Taya; Osamu Saitoh; Asako Kosuga; Masahiko Tatsumi; Kunitoshi Kamijima; Kozo Kaibuchi; Masatoshi Takeda; Hiroshi Kunugi

doi:10.1016/j.neures.2009.05.008

Association analysis between schizophrenia and the AP-3 complex genes

Ryota Hashimoto
, Kazutaka Ohi
, Takeya Okada
, Yuka Yasuda
, Hidenaga Yamamori
, Hiroaki Hori
, Takao Hikita
, Shinichiro Taya
, Osamu Saitoh
, Asako Kosuga
, Masahiko Tatsumi
, Kunitoshi Kamijima
, Kozo Kaibuchi
, Masatoshi Takeda
, Hiroshi Kunugi

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

9 被引用数 (Scopus)

抄録

A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia (χ² = 6.33, P = 0.012, odds ratio = 0.80) was no longer positive after correction for multiple testing (corrected P = 0.192). The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia in this population.

本文言語	英語
ページ（範囲）	113-115
ページ数	3
ジャーナル	Neuroscience Research
巻	65
号	1
DOI	https://doi.org/10.1016/j.neures.2009.05.008
出版ステータス	出版済み - 09-2009
外部発表	はい

All Science Journal Classification (ASJC) codes

神経科学一般

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10.1016/j.neures.2009.05.008

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title = "Association analysis between schizophrenia and the AP-3 complex genes",

abstract = "A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia (χ2 = 6.33, P = 0.012, odds ratio = 0.80) was no longer positive after correction for multiple testing (corrected P = 0.192). The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia in this population.",

keywords = "AP3M1, Adaptor protein (AP)-3 complex, Dysbindin, Schizophrenia, Single nucleotide polymorphism",

author = "Ryota Hashimoto and Kazutaka Ohi and Takeya Okada and Yuka Yasuda and Hidenaga Yamamori and Hiroaki Hori and Takao Hikita and Shinichiro Taya and Osamu Saitoh and Asako Kosuga and Masahiko Tatsumi and Kunitoshi Kamijima and Kozo Kaibuchi and Masatoshi Takeda and Hiroshi Kunugi",

note = "Funding Information: This work was supported in part by Grants-in-Aid from the Japanese Ministry of Health, Labor and Welfare (H18-kokoro-005, H19-kokoro-002). ",

year = "2009",

month = sep,

doi = "10.1016/j.neures.2009.05.008",

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T1 - Association analysis between schizophrenia and the AP-3 complex genes

AU - Hashimoto, Ryota

AU - Ohi, Kazutaka

AU - Okada, Takeya

AU - Yasuda, Yuka

AU - Yamamori, Hidenaga

AU - Hori, Hiroaki

AU - Hikita, Takao

AU - Taya, Shinichiro

AU - Saitoh, Osamu

AU - Kosuga, Asako

AU - Tatsumi, Masahiko

AU - Kamijima, Kunitoshi

AU - Kaibuchi, Kozo

AU - Takeda, Masatoshi

AU - Kunugi, Hiroshi

N1 - Funding Information: This work was supported in part by Grants-in-Aid from the Japanese Ministry of Health, Labor and Welfare (H18-kokoro-005, H19-kokoro-002).

PY - 2009/9

Y1 - 2009/9

N2 - A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia (χ2 = 6.33, P = 0.012, odds ratio = 0.80) was no longer positive after correction for multiple testing (corrected P = 0.192). The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia in this population.

AB - A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia (χ2 = 6.33, P = 0.012, odds ratio = 0.80) was no longer positive after correction for multiple testing (corrected P = 0.192). The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia in this population.

KW - AP3M1

KW - Adaptor protein (AP)-3 complex

KW - Dysbindin

KW - Schizophrenia

KW - Single nucleotide polymorphism

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UR - https://www.scopus.com/pages/publications/67650433833#tab=citedBy

U2 - 10.1016/j.neures.2009.05.008

DO - 10.1016/j.neures.2009.05.008

M3 - Article

C2 - 19481122

AN - SCOPUS:67650433833

SN - 0168-0102

VL - 65

SP - 113

EP - 115

JO - Neuroscience Research

JF - Neuroscience Research

IS - 1

ER -

Association analysis between schizophrenia and the AP-3 complex genes

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