Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia

R. Hashimoto, M. Yoshida, N. Ozaki, Y. Yamanouchi, N. Iwata, T. Suzuki, T. Kitajima, M. Tatsumi, K. Kamijima, H. Kunugi

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Two research groups have thus far reported a significant association between schizophrenia and a promoter polymorphism (-308G > A) of the gene encoding tumor necrosis factor alpha (TNF-α), while contradictive negative results have also been reported. We examined the possible association in a Japanese sample of 297 schizophrenia cases and 458 controls. Allele frequencies of both the patients and controls were very low (1.5% and 0.8%, respectively), and the difference was not statistically significant. We conclude that the effect of the -308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the -308G > A polymorphism of the TNF-α gene.

元の言語English
ページ(範囲)217-221
ページ数5
ジャーナルJournal of Neural Transmission
111
発行部数2
DOI
出版物ステータスPublished - 01-02-2004

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All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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