Association analysis of the NOD2 gene with susceptibility to graft-versus-host disease in a Japanese population

Tsuyoshi Tanabe, Natsu Yamaguchi, Koichi Matsuda, Keiko Yamazaki, Satoshi Takahashi, Arinobu Tojo, Makoto Onizuka, Yoshinobu Eishi, Hideki Akiyama, Jun Ishikawa, Takehiko Mori, Masamichi Hara, Kazutoshi Koike, Keisei Kawa, Takakazu Kawase, Yasuo Morishima, Hiroki Amano, Mikiko Kobayashi-Miura, Takeyasu Kakamu, Yusuke NakamuraShigetaka Asano, Yasuyuki Fujita

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Members of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family participate in the innate immune system, exerting widespread effects on cytokine secretion, autophagy, and apoptosis. Recent studies in Caucasians revealed the association between mutants of NOD2, a member of the NLR family, and severity of acute graft-versus-host disease (GVHD). NOD2 polymorphism screening has been recommended for donor selection and risk assessment at bone marrow transplantation. To investigate whether NOD2 plays a role in the pathogenesis of GVHD in a Japanese population, we examined DNA from 142 bone marrow transplant patient/donor pairs to detect genetic variation in the NOD2 gene. No genetic variants of NOD2 were associated with the severity of acute GVHD in our patients. However, a weak association between a single nucleotide polymorphism in the NOD2 gene (R471C) and acute myeloid leukemia in the bone marrow patients (p = 0.029, odds ratio 4.08, 95% CI 1.22-13.67) was detected. This polymorphism was not prevalent in 479 Crohn's disease (CD) patients in Japan. These results suggest that, in the Japanese population, unlike the Caucasian, NOD2 is not a major contributor to susceptibility to severe acute GVHD.

本文言語English
ページ(範囲)771-778
ページ数8
ジャーナルInternational Journal of Hematology
93
6
DOI
出版ステータスPublished - 06-2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • 血液学

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