Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population

Nagahide Takahashi, Ryoko Ishihara, Shinichi Saito, Nobuhisa Maemo, Nagisa Aoyama, Xiofei Ji, Hideki Miura, Masashi Ikeda, Nakao Iwata, Tatsuyo Suzuki, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Norio Ozaki, Toshiya Inada

研究成果: Article査読

14 被引用数 (Scopus)

抄録

It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p = 0.0269), and with a 2 marker haplotype (p = 0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p = 0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.

本文言語English
ページ(範囲)179-183
ページ数5
ジャーナルSchizophrenia Research
83
2-3
DOI
出版ステータスPublished - 04-2006

All Science Journal Classification (ASJC) codes

  • 精神医学および精神衛生
  • 生物学的精神医学

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