Association between CYP19A1 polymorphisms and sex hormones in postmenopausal Japanese women

Kumiko Kidokoro, Kazuhiko Ino, Kaoru Hirose, Hiroaki Kajiyama, Satoyo Hosono, Takeshi Suzuki, Takakazu Kawase, Akio Hiraki, Nobuyuki Hamajima, Hideo Tanaka, Kazuo Tajima, Fumitaka Kikkawa, Keitaro Matsuo

研究成果: ジャーナルへの寄稿学術論文査読

21 被引用数 (Scopus)

抄録

In postmenopausal women, extraovarian sex hormone production plays an important role in hormone-related diseases, such as breast and endometrial cancers. Aromatase, an enzyme encoded by CYP19A1, is a key enzyme involved in estrogen biosynthesis. The impact of CYP19A1 polymorphisms on serum sex hormone levels in the Japanese population has never been investigated. This study enrolled 100 postmenopausal Japanese women found to be without cancer. Twenty-five CYP19A1 loci were identified, and measurements were conducted on serum levels of sex hormones; lifestyle data were collected, namely estrone (E1), estradiol (E2), testosterone and sex hormone-binding globulin (SHBG). We conducted a cross-sectional analysis to evaluate the impact of CYP19A1 haplotype on serum sex hormone levels. We found that subjects with BMI≥25 kg/m 2 showed a significant difference in circulating testosterone levels (0.29±0.19, P=0.050). Neither age nor the amount of physical exercise or drinking habits showed any effect on hormone levels. We identified seven haplotype blocks in CYP19A1 by LD analysis. Estrone levels differed in rs12148604 (SNP 1) and rs11632903 (SNP14). No significant locus for estradiol was observed. SHBG levels were associated with rs4441215 (SNP11). Testosterone levels were strongly associated with rs752760 (SNP24) and rs2445768 (SNP25) and weakly associated with SNP 1, SNP11 and SNP14 as well. We found that polymorphisms in CYP19A1 influence sex hormone levels in Japanese postmenopausal women.

本文言語英語
ページ(範囲)78-85
ページ数8
ジャーナルJournal of Human Genetics
54
2
DOI
出版ステータス出版済み - 02-2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • 遺伝学
  • 遺伝学(臨床)

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