Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder

Nagisa Aoyama, Nagahide Takahashi, Kiyoyuki Kitaichi, Ryoko Ishihara, Shinichi Saito, Nobuhisa Maeno, Xiaofei Ji, Kenji Takagi, Yoshimoto Sekine, Masaomi Iyo, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Ichiro Sora, Hiroshi Ujike, Nakao Iwata, Toshiya Inada, Norio Ozaki

研究成果: Article

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Background: Methamphetamine (MAP) is one of the most frequently used illegal substances in Japan, and family and twin studies have suggested that genetic factors contribute to psychostimulant dependence, including MAP dependence. Organic cation transporter 3 (OCT3) has been reported to be involved in the disposition of MAP as well as MAP-induced behavioral changes in animals. Moreover, SLC22A3 (which encodes OCT3) is a candidate gene for MAP dependence because it is located within a chromosomal region associated with substance dependence. Methods: Using 96 healthy control subjects, linkage disequilibrium (LD) within the SLC22A3 was investigated, and 5 single-nucleotide polymorphisms (SNPs) were selected as haplotype tag SNPs to search for an association with MAP dependence. Single-marker analyses and haplotype analyses of these SNPs were performed in 213 subjects with MAP dependence and 443 healthy controls. Results: SLC22A3 polymorphisms were not significantly associated with MAP dependence in any of the single-marker and haplotype analyses. When subjects with MAP dependence were divided into polysubstance and single-MAP users, genotype and allele frequency of SNP2 (p=0.024, p=0.011, respectively), allele frequency of SNP3 (p=0.037), and haplotypic frequencies for these 2 SNPs (p=0.0438) differed significantly between groups. Conclusions: These results suggest that polymorphisms of SLC22A3 are related to the development of polysubstance use in Japanese patients with MAP dependence.

元の言語English
ページ(範囲)1644-1649
ページ数6
ジャーナルAlcoholism: Clinical and Experimental Research
30
発行部数10
DOI
出版物ステータスPublished - 10-2006

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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    Aoyama, N., Takahashi, N., Kitaichi, K., Ishihara, R., Saito, S., Maeno, N., Ji, X., Takagi, K., Sekine, Y., Iyo, M., Harano, M., Komiyama, T., Yamada, M., Sora, I., Ujike, H., Iwata, N., Inada, T., & Ozaki, N. (2006). Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder. Alcoholism: Clinical and Experimental Research, 30(10), 1644-1649. https://doi.org/10.1111/j.1530-0277.2006.00215.x