TY - JOUR
T1 - Association of abdominal circumference with serum nitric oxide concentration in healthy population
AU - Kondo, Takaaki
AU - Ueyama, Jun
AU - Imai, Ryota
AU - Suzuki, Koji
AU - Ito, Yoshinori
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research to T. Kondo from the Ministry of Education, Culture, Sports, Science and Technology of Japan (No. 17390184).
PY - 2006
Y1 - 2006
N2 - Objectives: We determined the relationship between abdominal circumference and the concentration of nitric oxide (NO), an endothelial cell product known to play an important role in the regulation of vascular tone and thrombocyte activations. Methods: Subjects were 177 men and 339 women aged 40 or over who were free from a history of diabetes or malignancy. Analysis of covariance was applied to examine the gender-specific and smoking-status-specific associations of abdominal fat volume measured as waist circumference, waist-hip ratio, and waist-to-stature ratio, with serum NO level represented by the concentration of NO metabolites (NOx; nitrate plus nitrite). Results: Although men showed no statistical association between abdominal fat accumulation and NOx concentration, abdominal adiposity seemed to inversely affect the serum NOx concentration of never- and current-smoking women. Conclusion: Our results suggest that a reduction in NO bioactivity occurs with abdominal fat accumulation in women. The underlying biological mechanism might involve adipocytokines secreted from visceral fat, but is yet to be elucidated.
AB - Objectives: We determined the relationship between abdominal circumference and the concentration of nitric oxide (NO), an endothelial cell product known to play an important role in the regulation of vascular tone and thrombocyte activations. Methods: Subjects were 177 men and 339 women aged 40 or over who were free from a history of diabetes or malignancy. Analysis of covariance was applied to examine the gender-specific and smoking-status-specific associations of abdominal fat volume measured as waist circumference, waist-hip ratio, and waist-to-stature ratio, with serum NO level represented by the concentration of NO metabolites (NOx; nitrate plus nitrite). Results: Although men showed no statistical association between abdominal fat accumulation and NOx concentration, abdominal adiposity seemed to inversely affect the serum NOx concentration of never- and current-smoking women. Conclusion: Our results suggest that a reduction in NO bioactivity occurs with abdominal fat accumulation in women. The underlying biological mechanism might involve adipocytokines secreted from visceral fat, but is yet to be elucidated.
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U2 - 10.1265/ehpm.11.321
DO - 10.1265/ehpm.11.321
M3 - Article
C2 - 21432362
AN - SCOPUS:33751572868
VL - 11
SP - 321
EP - 325
JO - Environmental Health and Preventive Medicine
JF - Environmental Health and Preventive Medicine
SN - 1342-078X
IS - 6
ER -