抄録
Background: Most studies of plasma adiponectin (APN) and mortality among community-dwelling elderly focus on cardiovascular disease, but data on the relationship between plasma APN and cancer mortality is exiguous. We investigated whether APN is associated with cancer mortality in community-dwelling elderly people. Methods: We conducted a case-cohort study within the New Integrated Suburban Seniority Investigation (NISSIN) Project using a randomly drawn sub-cohort of 697 subjects (351 men and 346 women; mean age 64.5 [standard deviation, 0.5] years) among whom we compared cases of all-cause death (n = 269) and cancer death (n = 149) during a mean follow-up duration of 10.8 (standard deviation, 3.7) years. Associations between APN and mortality were assessed using weighted Cox regression analyses. Results: We observed significant positive associations between the APN concentration and cancer death in the first and third APN tertiles compared with the second APN tertile (hazard ratio [HR]T1 vs T2, 1.67; 95% confidence interval [CI], 1.00–2.79 and HRT3 vs T2, 2.10; 95% CI, 1.30–3.40). Further adjustment for possible confounders attenuated the association (HRT1 vs T2, 1.63; 95% CI, 0.93–2.84 and HRT3 vs T2, 2.10; 95% CI, 1.26–3.50). A similar but weaker association was seen for all-cause mortality (multivariate HRT1 vs T2, 1.45; 95% CI, 0.95–2.21 and HRT3 vs T2, 1.51; 95% CI, 1.01–2.25). Conclusion: Plasma APN and cancer mortality have a significant relationship among community-dwelling elderly people, which warrants further study.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 367-372 |
| ページ数 | 6 |
| ジャーナル | Journal of epidemiology |
| 巻 | 28 |
| 発行部数 | 8 |
| DOI | |
| 出版物ステータス | Published - 01-01-2018 |
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All Science Journal Classification (ASJC) codes
- Epidemiology
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Association of adiponectin with cancer and all-cause mortality in a japanese community-dwelling elderly cohort : A case-cohort study. / Kojima, Reiji; Ukawa, Shigekazu; Zhao, Wenjing; Suzuki, Koji; Yamada, Hiroya; Tsushita, Kazuyo; Kawamura, Takashi; Okabayashi, Satoe; Wakai, Kenji; Noma, Hisashi; Ando, Masahiko; Tamakoshi, Akiko.
：: Journal of epidemiology, 巻 28, 番号 8, 01.01.2018, p. 367-372.研究成果: Article
TY - JOUR
T1 - Association of adiponectin with cancer and all-cause mortality in a japanese community-dwelling elderly cohort
T2 - A case-cohort study
AU - Kojima, Reiji
AU - Ukawa, Shigekazu
AU - Zhao, Wenjing
AU - Suzuki, Koji
AU - Yamada, Hiroya
AU - Tsushita, Kazuyo
AU - Kawamura, Takashi
AU - Okabayashi, Satoe
AU - Wakai, Kenji
AU - Noma, Hisashi
AU - Ando, Masahiko
AU - Tamakoshi, Akiko
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: Most studies of plasma adiponectin (APN) and mortality among community-dwelling elderly focus on cardiovascular disease, but data on the relationship between plasma APN and cancer mortality is exiguous. We investigated whether APN is associated with cancer mortality in community-dwelling elderly people. Methods: We conducted a case-cohort study within the New Integrated Suburban Seniority Investigation (NISSIN) Project using a randomly drawn sub-cohort of 697 subjects (351 men and 346 women; mean age 64.5 [standard deviation, 0.5] years) among whom we compared cases of all-cause death (n = 269) and cancer death (n = 149) during a mean follow-up duration of 10.8 (standard deviation, 3.7) years. Associations between APN and mortality were assessed using weighted Cox regression analyses. Results: We observed significant positive associations between the APN concentration and cancer death in the first and third APN tertiles compared with the second APN tertile (hazard ratio [HR]T1 vs T2, 1.67; 95% confidence interval [CI], 1.00–2.79 and HRT3 vs T2, 2.10; 95% CI, 1.30–3.40). Further adjustment for possible confounders attenuated the association (HRT1 vs T2, 1.63; 95% CI, 0.93–2.84 and HRT3 vs T2, 2.10; 95% CI, 1.26–3.50). A similar but weaker association was seen for all-cause mortality (multivariate HRT1 vs T2, 1.45; 95% CI, 0.95–2.21 and HRT3 vs T2, 1.51; 95% CI, 1.01–2.25). Conclusion: Plasma APN and cancer mortality have a significant relationship among community-dwelling elderly people, which warrants further study.
AB - Background: Most studies of plasma adiponectin (APN) and mortality among community-dwelling elderly focus on cardiovascular disease, but data on the relationship between plasma APN and cancer mortality is exiguous. We investigated whether APN is associated with cancer mortality in community-dwelling elderly people. Methods: We conducted a case-cohort study within the New Integrated Suburban Seniority Investigation (NISSIN) Project using a randomly drawn sub-cohort of 697 subjects (351 men and 346 women; mean age 64.5 [standard deviation, 0.5] years) among whom we compared cases of all-cause death (n = 269) and cancer death (n = 149) during a mean follow-up duration of 10.8 (standard deviation, 3.7) years. Associations between APN and mortality were assessed using weighted Cox regression analyses. Results: We observed significant positive associations between the APN concentration and cancer death in the first and third APN tertiles compared with the second APN tertile (hazard ratio [HR]T1 vs T2, 1.67; 95% confidence interval [CI], 1.00–2.79 and HRT3 vs T2, 2.10; 95% CI, 1.30–3.40). Further adjustment for possible confounders attenuated the association (HRT1 vs T2, 1.63; 95% CI, 0.93–2.84 and HRT3 vs T2, 2.10; 95% CI, 1.26–3.50). A similar but weaker association was seen for all-cause mortality (multivariate HRT1 vs T2, 1.45; 95% CI, 0.95–2.21 and HRT3 vs T2, 1.51; 95% CI, 1.01–2.25). Conclusion: Plasma APN and cancer mortality have a significant relationship among community-dwelling elderly people, which warrants further study.
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U2 - 10.2188/jea.JE20170087
DO - 10.2188/jea.JE20170087
M3 - Article
C2 - 29576602
AN - SCOPUS:85051767315
VL - 28
SP - 367
EP - 372
JO - Journal of Epidemiology
JF - Journal of Epidemiology
SN - 0917-5040
IS - 8
ER -