TY - JOUR
T1 - Association of adiponectin with cancer and all-cause mortality in a japanese community-dwelling elderly cohort
T2 - A case-cohort study
AU - Kojima, Reiji
AU - Ukawa, Shigekazu
AU - Zhao, Wenjing
AU - Suzuki, Koji
AU - Yamada, Hiroya
AU - Tsushita, Kazuyo
AU - Kawamura, Takashi
AU - Okabayashi, Satoe
AU - Wakai, Kenji
AU - Noma, Hisashi
AU - Ando, Masahiko
AU - Tamakoshi, Akiko
N1 - Funding Information:
Role of funding source: This study was supported by JSPS KAKENHI Grant Numbers JP15390197, JP25893003, JP2646760, and JP26520105; The Uehara Memorial Foundation; Mitsui Sumitomo Insurance Welfare Foundation; Health Promotion Foundation; and Pfizer Health Research Foundation.
Funding Information:
The authors express their sincere appreciation to the Health Center and Hygiene Department of Nisshin City for their generous cooperation in collecting the baseline and follow-up data. The authors also thank Angela Morben, DVM, ELS, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript. Conflicts of interest: None declared. Authors' contributions: R Kojima contributed to the study conception, analysis and interpretation of the data, and preparation of the manuscript. S Ukawa, H Noma, and W Zhao contributed to the analysis and interpretation of the data, critical review, and feedback. M Tsushita contributed to the interpretation of the data, critical review, and feedback. T Kawamura contributed to the study design, acquisition of the data, critical review, and feedback. K Wakai, S Okabayashi, K Suzuki, H Yamada, and K Ando contributed to the acquisition of the data, critical review, and feedback. A Tamakoshi contributed to the study design, acquisition and interpretation of the data, critical review, and feedback. Role of funding source: This study was supported by JSPS KAKENHI Grant Numbers JP15390197, JP25893003, JP2646760, and JP26520105; The Uehara Memorial Foundation; Mitsui Sumitomo Insurance Welfare Foundation; Health Promotion Foundation; and Pfizer Health Research Foundation.
Publisher Copyright:
© 2018 Reiji Kojima et al.
PY - 2018
Y1 - 2018
N2 - Background: Most studies of plasma adiponectin (APN) and mortality among community-dwelling elderly focus on cardiovascular disease, but data on the relationship between plasma APN and cancer mortality is exiguous. We investigated whether APN is associated with cancer mortality in community-dwelling elderly people. Methods: We conducted a case-cohort study within the New Integrated Suburban Seniority Investigation (NISSIN) Project using a randomly drawn sub-cohort of 697 subjects (351 men and 346 women; mean age 64.5 [standard deviation, 0.5] years) among whom we compared cases of all-cause death (n = 269) and cancer death (n = 149) during a mean follow-up duration of 10.8 (standard deviation, 3.7) years. Associations between APN and mortality were assessed using weighted Cox regression analyses. Results: We observed significant positive associations between the APN concentration and cancer death in the first and third APN tertiles compared with the second APN tertile (hazard ratio [HR]T1 vs T2, 1.67; 95% confidence interval [CI], 1.00–2.79 and HRT3 vs T2, 2.10; 95% CI, 1.30–3.40). Further adjustment for possible confounders attenuated the association (HRT1 vs T2, 1.63; 95% CI, 0.93–2.84 and HRT3 vs T2, 2.10; 95% CI, 1.26–3.50). A similar but weaker association was seen for all-cause mortality (multivariate HRT1 vs T2, 1.45; 95% CI, 0.95–2.21 and HRT3 vs T2, 1.51; 95% CI, 1.01–2.25). Conclusion: Plasma APN and cancer mortality have a significant relationship among community-dwelling elderly people, which warrants further study.
AB - Background: Most studies of plasma adiponectin (APN) and mortality among community-dwelling elderly focus on cardiovascular disease, but data on the relationship between plasma APN and cancer mortality is exiguous. We investigated whether APN is associated with cancer mortality in community-dwelling elderly people. Methods: We conducted a case-cohort study within the New Integrated Suburban Seniority Investigation (NISSIN) Project using a randomly drawn sub-cohort of 697 subjects (351 men and 346 women; mean age 64.5 [standard deviation, 0.5] years) among whom we compared cases of all-cause death (n = 269) and cancer death (n = 149) during a mean follow-up duration of 10.8 (standard deviation, 3.7) years. Associations between APN and mortality were assessed using weighted Cox regression analyses. Results: We observed significant positive associations between the APN concentration and cancer death in the first and third APN tertiles compared with the second APN tertile (hazard ratio [HR]T1 vs T2, 1.67; 95% confidence interval [CI], 1.00–2.79 and HRT3 vs T2, 2.10; 95% CI, 1.30–3.40). Further adjustment for possible confounders attenuated the association (HRT1 vs T2, 1.63; 95% CI, 0.93–2.84 and HRT3 vs T2, 2.10; 95% CI, 1.26–3.50). A similar but weaker association was seen for all-cause mortality (multivariate HRT1 vs T2, 1.45; 95% CI, 0.95–2.21 and HRT3 vs T2, 1.51; 95% CI, 1.01–2.25). Conclusion: Plasma APN and cancer mortality have a significant relationship among community-dwelling elderly people, which warrants further study.
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U2 - 10.2188/jea.JE20170087
DO - 10.2188/jea.JE20170087
M3 - Article
C2 - 29576602
AN - SCOPUS:85051767315
VL - 28
SP - 367
EP - 372
JO - Journal of Epidemiology
JF - Journal of Epidemiology
SN - 0917-5040
IS - 8
ER -