Association of adiponectin with cancer and all-cause mortality in a japanese community-dwelling elderly cohort: A case-cohort study

Reiji Kojima, Shigekazu Ukawa, Wenjing Zhao, Koji Suzuki, Hiroya Yamada, Kazuyo Tsushita, Takashi Kawamura, Satoe Okabayashi, Kenji Wakai, Hisashi Noma, Masahiko Ando, Akiko Tamakoshi

研究成果: Article

抄録

Background: Most studies of plasma adiponectin (APN) and mortality among community-dwelling elderly focus on cardiovascular disease, but data on the relationship between plasma APN and cancer mortality is exiguous. We investigated whether APN is associated with cancer mortality in community-dwelling elderly people. Methods: We conducted a case-cohort study within the New Integrated Suburban Seniority Investigation (NISSIN) Project using a randomly drawn sub-cohort of 697 subjects (351 men and 346 women; mean age 64.5 [standard deviation, 0.5] years) among whom we compared cases of all-cause death (n = 269) and cancer death (n = 149) during a mean follow-up duration of 10.8 (standard deviation, 3.7) years. Associations between APN and mortality were assessed using weighted Cox regression analyses. Results: We observed significant positive associations between the APN concentration and cancer death in the first and third APN tertiles compared with the second APN tertile (hazard ratio [HR]T1 vs T2, 1.67; 95% confidence interval [CI], 1.00–2.79 and HRT3 vs T2, 2.10; 95% CI, 1.30–3.40). Further adjustment for possible confounders attenuated the association (HRT1 vs T2, 1.63; 95% CI, 0.93–2.84 and HRT3 vs T2, 2.10; 95% CI, 1.26–3.50). A similar but weaker association was seen for all-cause mortality (multivariate HRT1 vs T2, 1.45; 95% CI, 0.95–2.21 and HRT3 vs T2, 1.51; 95% CI, 1.01–2.25). Conclusion: Plasma APN and cancer mortality have a significant relationship among community-dwelling elderly people, which warrants further study.

元の言語English
ページ(範囲)367-372
ページ数6
ジャーナルJournal of epidemiology
28
発行部数8
DOI
出版物ステータスPublished - 01-01-2018

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Independent Living
Adiponectin
Cohort Studies
Mortality
Confidence Intervals
Neoplasms
Cause of Death
Cardiovascular Diseases
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Epidemiology

これを引用

Kojima, Reiji ; Ukawa, Shigekazu ; Zhao, Wenjing ; Suzuki, Koji ; Yamada, Hiroya ; Tsushita, Kazuyo ; Kawamura, Takashi ; Okabayashi, Satoe ; Wakai, Kenji ; Noma, Hisashi ; Ando, Masahiko ; Tamakoshi, Akiko. / Association of adiponectin with cancer and all-cause mortality in a japanese community-dwelling elderly cohort : A case-cohort study. :: Journal of epidemiology. 2018 ; 巻 28, 番号 8. pp. 367-372.
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title = "Association of adiponectin with cancer and all-cause mortality in a japanese community-dwelling elderly cohort: A case-cohort study",
abstract = "Background: Most studies of plasma adiponectin (APN) and mortality among community-dwelling elderly focus on cardiovascular disease, but data on the relationship between plasma APN and cancer mortality is exiguous. We investigated whether APN is associated with cancer mortality in community-dwelling elderly people. Methods: We conducted a case-cohort study within the New Integrated Suburban Seniority Investigation (NISSIN) Project using a randomly drawn sub-cohort of 697 subjects (351 men and 346 women; mean age 64.5 [standard deviation, 0.5] years) among whom we compared cases of all-cause death (n = 269) and cancer death (n = 149) during a mean follow-up duration of 10.8 (standard deviation, 3.7) years. Associations between APN and mortality were assessed using weighted Cox regression analyses. Results: We observed significant positive associations between the APN concentration and cancer death in the first and third APN tertiles compared with the second APN tertile (hazard ratio [HR]T1 vs T2, 1.67; 95{\%} confidence interval [CI], 1.00–2.79 and HRT3 vs T2, 2.10; 95{\%} CI, 1.30–3.40). Further adjustment for possible confounders attenuated the association (HRT1 vs T2, 1.63; 95{\%} CI, 0.93–2.84 and HRT3 vs T2, 2.10; 95{\%} CI, 1.26–3.50). A similar but weaker association was seen for all-cause mortality (multivariate HRT1 vs T2, 1.45; 95{\%} CI, 0.95–2.21 and HRT3 vs T2, 1.51; 95{\%} CI, 1.01–2.25). Conclusion: Plasma APN and cancer mortality have a significant relationship among community-dwelling elderly people, which warrants further study.",
author = "Reiji Kojima and Shigekazu Ukawa and Wenjing Zhao and Koji Suzuki and Hiroya Yamada and Kazuyo Tsushita and Takashi Kawamura and Satoe Okabayashi and Kenji Wakai and Hisashi Noma and Masahiko Ando and Akiko Tamakoshi",
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doi = "10.2188/jea.JE20170087",
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Kojima, R, Ukawa, S, Zhao, W, Suzuki, K, Yamada, H, Tsushita, K, Kawamura, T, Okabayashi, S, Wakai, K, Noma, H, Ando, M & Tamakoshi, A 2018, 'Association of adiponectin with cancer and all-cause mortality in a japanese community-dwelling elderly cohort: A case-cohort study', Journal of epidemiology, 巻. 28, 番号 8, pp. 367-372. https://doi.org/10.2188/jea.JE20170087

Association of adiponectin with cancer and all-cause mortality in a japanese community-dwelling elderly cohort : A case-cohort study. / Kojima, Reiji; Ukawa, Shigekazu; Zhao, Wenjing; Suzuki, Koji; Yamada, Hiroya; Tsushita, Kazuyo; Kawamura, Takashi; Okabayashi, Satoe; Wakai, Kenji; Noma, Hisashi; Ando, Masahiko; Tamakoshi, Akiko.

:: Journal of epidemiology, 巻 28, 番号 8, 01.01.2018, p. 367-372.

研究成果: Article

TY - JOUR

T1 - Association of adiponectin with cancer and all-cause mortality in a japanese community-dwelling elderly cohort

T2 - A case-cohort study

AU - Kojima, Reiji

AU - Ukawa, Shigekazu

AU - Zhao, Wenjing

AU - Suzuki, Koji

AU - Yamada, Hiroya

AU - Tsushita, Kazuyo

AU - Kawamura, Takashi

AU - Okabayashi, Satoe

AU - Wakai, Kenji

AU - Noma, Hisashi

AU - Ando, Masahiko

AU - Tamakoshi, Akiko

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Most studies of plasma adiponectin (APN) and mortality among community-dwelling elderly focus on cardiovascular disease, but data on the relationship between plasma APN and cancer mortality is exiguous. We investigated whether APN is associated with cancer mortality in community-dwelling elderly people. Methods: We conducted a case-cohort study within the New Integrated Suburban Seniority Investigation (NISSIN) Project using a randomly drawn sub-cohort of 697 subjects (351 men and 346 women; mean age 64.5 [standard deviation, 0.5] years) among whom we compared cases of all-cause death (n = 269) and cancer death (n = 149) during a mean follow-up duration of 10.8 (standard deviation, 3.7) years. Associations between APN and mortality were assessed using weighted Cox regression analyses. Results: We observed significant positive associations between the APN concentration and cancer death in the first and third APN tertiles compared with the second APN tertile (hazard ratio [HR]T1 vs T2, 1.67; 95% confidence interval [CI], 1.00–2.79 and HRT3 vs T2, 2.10; 95% CI, 1.30–3.40). Further adjustment for possible confounders attenuated the association (HRT1 vs T2, 1.63; 95% CI, 0.93–2.84 and HRT3 vs T2, 2.10; 95% CI, 1.26–3.50). A similar but weaker association was seen for all-cause mortality (multivariate HRT1 vs T2, 1.45; 95% CI, 0.95–2.21 and HRT3 vs T2, 1.51; 95% CI, 1.01–2.25). Conclusion: Plasma APN and cancer mortality have a significant relationship among community-dwelling elderly people, which warrants further study.

AB - Background: Most studies of plasma adiponectin (APN) and mortality among community-dwelling elderly focus on cardiovascular disease, but data on the relationship between plasma APN and cancer mortality is exiguous. We investigated whether APN is associated with cancer mortality in community-dwelling elderly people. Methods: We conducted a case-cohort study within the New Integrated Suburban Seniority Investigation (NISSIN) Project using a randomly drawn sub-cohort of 697 subjects (351 men and 346 women; mean age 64.5 [standard deviation, 0.5] years) among whom we compared cases of all-cause death (n = 269) and cancer death (n = 149) during a mean follow-up duration of 10.8 (standard deviation, 3.7) years. Associations between APN and mortality were assessed using weighted Cox regression analyses. Results: We observed significant positive associations between the APN concentration and cancer death in the first and third APN tertiles compared with the second APN tertile (hazard ratio [HR]T1 vs T2, 1.67; 95% confidence interval [CI], 1.00–2.79 and HRT3 vs T2, 2.10; 95% CI, 1.30–3.40). Further adjustment for possible confounders attenuated the association (HRT1 vs T2, 1.63; 95% CI, 0.93–2.84 and HRT3 vs T2, 2.10; 95% CI, 1.26–3.50). A similar but weaker association was seen for all-cause mortality (multivariate HRT1 vs T2, 1.45; 95% CI, 0.95–2.21 and HRT3 vs T2, 1.51; 95% CI, 1.01–2.25). Conclusion: Plasma APN and cancer mortality have a significant relationship among community-dwelling elderly people, which warrants further study.

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U2 - 10.2188/jea.JE20170087

DO - 10.2188/jea.JE20170087

M3 - Article

C2 - 29576602

AN - SCOPUS:85051767315

VL - 28

SP - 367

EP - 372

JO - Journal of Epidemiology

JF - Journal of Epidemiology

SN - 0917-5040

IS - 8

ER -