Association of adiponectin with carotid arteriosclerosis in predialysis chronic kidney disease

Mutsuharu Hayashi, Rei Shibata, Hiroshi Takahashi, Hideki Ishii, Toru Aoyama, Hirotake Kasuga, Shigeki Yamada, Koji Ohashi, Syoichi Maruyama, Seiichi Matsuo, Noriyuki Ouchi, Toyoaki Murohara, Takanobu Toriyama

研究成果: Article査読

20 被引用数 (Scopus)

抄録

Background/Aims: Adiponectin is an adipocyte-derived protein with antiatherogenic properties. Chronic kidney disease (CKD) is one of the risk factors for cardiovascular disease. We investigated the potential association between adiponectin and carotid arteriosclerosis in patients with predialysis CKD. Methods: We enrolled 95 CKD patients without dialysis and 81 non-CKD patients. Intima-media thickness (IMT) and plaque score (PS) in the common carotid artery were measured using an ultrasound system. Carotid arteriosclerosis was defined as IMT >1.2 mm and/or PS >5.0 mm. Results: The prevalence of CKD was independently associated with carotid arteriosclerosis after adjustment for other risk factors. Higher adiponectin levels were observed in CKD patients compared with non-CKD patients. Adiponectin levels were not independently correlated with the presence of carotid arteriosclerosis in all subjects. To evaluate the association between adiponectin and carotid arteriosclerosis among a CKD population, we divided the CKD patients into 2 groups according to a cutoff level of adiponectin determined by ROC analysis. The prevalence of carotid arteriosclerosis was significantly higher in the low-adiponectin group than in the high-adiponectin group among CKD patients. After adjusting for other risk factors, low levels of adiponectin were independently correlated with carotid arteriosclerosis in CKD patients. Conclusion: Our data document that adiponectin is associated with increased risk of carotid atherosclerosis in a predialysis CKD population.

本文言語English
ページ(範囲)249-255
ページ数7
ジャーナルAmerican Journal of Nephrology
34
3
DOI
出版ステータスPublished - 09-2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • Nephrology

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