Association of genetic polymorphisms in DNMT3A with the progression of gastric mucosal atrophy and susceptibility to gastric cancer in Japan

Wu Jing, Toshimi Otsuka, Masakatsu Nakamura, Naoko Sakurai, Hikaru Takano, Tasuku Hayashi, Masafumi Ota, Tomoe Nomura, Ranji Hayashi, Takeo Shimasaki, Tomomitsu Tahara, Tomoyuki Shibata, Tomiyasu Arisawa

研究成果: Article

抄録

The aim of the present study was to investigate whether single nucleotide polymorphisms in the DNMT3A gene are associated with susceptibility to gastric cancer in the Japanese population. The present case-control study examined the associations between single nucleotide polymorphisms (rs6733868 and rs13428812) in DNMT3A and cancer susceptibility in 343 patients with gastric cancer and 708 subjects without gastric malignancies on upper gastro-duodenal endoscopy. Of 708 controls, 409 were classified into two groups histologically: 99 cases with and 310 cases without gastric mucosal atrophy. Overall, homozygosity for the DNMT3A rs6733868 minor allele was significantly associated with a reduced risk of gastric cancer (odds ratio [OR], 0.621; 95% confidence interval [CI], 0.402-0.958; P=0.031), especially of the intestinal type (OR, 0.494; 95% CI, 0.274-0.890; P=0.019). In subjects >60 years, rs6733868 minor allele homozygosity was significantly associated with gastric cancer susceptibility. Carriers of the rs6733868 minor allele had a reduced risk of severe gastric mucosal atrophy (OR, 0.495; 95% CI, 0.299-0.826; P=0.0069). In addition, the number of minor alleles of both rs6733868 and rs13428812 was significantly correlated with the risk of Helicobacter pylori (HP) infection (P=0.0070 and P=0.0050, respectively). However, rs13428812 was not associated with severe gastric mucosal atrophy or gastric carcinogenesis. The present results suggest that DNMT3A polymorphisms serve roles in the progression from HP infection to gastric mucosal atrophy and gastric carcinogenesis in terms of degree and manner.

元の言語English
ページ(範囲)3482-3488
ページ数7
ジャーナルOncology Letters
17
発行部数3
DOI
出版物ステータスPublished - 01-03-2019

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Genetic Polymorphisms
Stomach Neoplasms
Atrophy
Stomach
Japan
Alleles
Odds Ratio
Helicobacter Infections
Confidence Intervals
Helicobacter pylori
Single Nucleotide Polymorphism
Carcinogenesis
Endoscopy
Case-Control Studies
Neoplasms
Population
Genes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Jing, Wu ; Otsuka, Toshimi ; Nakamura, Masakatsu ; Sakurai, Naoko ; Takano, Hikaru ; Hayashi, Tasuku ; Ota, Masafumi ; Nomura, Tomoe ; Hayashi, Ranji ; Shimasaki, Takeo ; Tahara, Tomomitsu ; Shibata, Tomoyuki ; Arisawa, Tomiyasu. / Association of genetic polymorphisms in DNMT3A with the progression of gastric mucosal atrophy and susceptibility to gastric cancer in Japan. :: Oncology Letters. 2019 ; 巻 17, 番号 3. pp. 3482-3488.
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title = "Association of genetic polymorphisms in DNMT3A with the progression of gastric mucosal atrophy and susceptibility to gastric cancer in Japan",
abstract = "The aim of the present study was to investigate whether single nucleotide polymorphisms in the DNMT3A gene are associated with susceptibility to gastric cancer in the Japanese population. The present case-control study examined the associations between single nucleotide polymorphisms (rs6733868 and rs13428812) in DNMT3A and cancer susceptibility in 343 patients with gastric cancer and 708 subjects without gastric malignancies on upper gastro-duodenal endoscopy. Of 708 controls, 409 were classified into two groups histologically: 99 cases with and 310 cases without gastric mucosal atrophy. Overall, homozygosity for the DNMT3A rs6733868 minor allele was significantly associated with a reduced risk of gastric cancer (odds ratio [OR], 0.621; 95{\%} confidence interval [CI], 0.402-0.958; P=0.031), especially of the intestinal type (OR, 0.494; 95{\%} CI, 0.274-0.890; P=0.019). In subjects >60 years, rs6733868 minor allele homozygosity was significantly associated with gastric cancer susceptibility. Carriers of the rs6733868 minor allele had a reduced risk of severe gastric mucosal atrophy (OR, 0.495; 95{\%} CI, 0.299-0.826; P=0.0069). In addition, the number of minor alleles of both rs6733868 and rs13428812 was significantly correlated with the risk of Helicobacter pylori (HP) infection (P=0.0070 and P=0.0050, respectively). However, rs13428812 was not associated with severe gastric mucosal atrophy or gastric carcinogenesis. The present results suggest that DNMT3A polymorphisms serve roles in the progression from HP infection to gastric mucosal atrophy and gastric carcinogenesis in terms of degree and manner.",
author = "Wu Jing and Toshimi Otsuka and Masakatsu Nakamura and Naoko Sakurai and Hikaru Takano and Tasuku Hayashi and Masafumi Ota and Tomoe Nomura and Ranji Hayashi and Takeo Shimasaki and Tomomitsu Tahara and Tomoyuki Shibata and Tomiyasu Arisawa",
year = "2019",
month = "3",
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doi = "10.3892/ol.2019.9948",
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Jing, W, Otsuka, T, Nakamura, M, Sakurai, N, Takano, H, Hayashi, T, Ota, M, Nomura, T, Hayashi, R, Shimasaki, T, Tahara, T, Shibata, T & Arisawa, T 2019, 'Association of genetic polymorphisms in DNMT3A with the progression of gastric mucosal atrophy and susceptibility to gastric cancer in Japan', Oncology Letters, 巻. 17, 番号 3, pp. 3482-3488. https://doi.org/10.3892/ol.2019.9948

Association of genetic polymorphisms in DNMT3A with the progression of gastric mucosal atrophy and susceptibility to gastric cancer in Japan. / Jing, Wu; Otsuka, Toshimi; Nakamura, Masakatsu; Sakurai, Naoko; Takano, Hikaru; Hayashi, Tasuku; Ota, Masafumi; Nomura, Tomoe; Hayashi, Ranji; Shimasaki, Takeo; Tahara, Tomomitsu; Shibata, Tomoyuki; Arisawa, Tomiyasu.

:: Oncology Letters, 巻 17, 番号 3, 01.03.2019, p. 3482-3488.

研究成果: Article

TY - JOUR

T1 - Association of genetic polymorphisms in DNMT3A with the progression of gastric mucosal atrophy and susceptibility to gastric cancer in Japan

AU - Jing, Wu

AU - Otsuka, Toshimi

AU - Nakamura, Masakatsu

AU - Sakurai, Naoko

AU - Takano, Hikaru

AU - Hayashi, Tasuku

AU - Ota, Masafumi

AU - Nomura, Tomoe

AU - Hayashi, Ranji

AU - Shimasaki, Takeo

AU - Tahara, Tomomitsu

AU - Shibata, Tomoyuki

AU - Arisawa, Tomiyasu

PY - 2019/3/1

Y1 - 2019/3/1

N2 - The aim of the present study was to investigate whether single nucleotide polymorphisms in the DNMT3A gene are associated with susceptibility to gastric cancer in the Japanese population. The present case-control study examined the associations between single nucleotide polymorphisms (rs6733868 and rs13428812) in DNMT3A and cancer susceptibility in 343 patients with gastric cancer and 708 subjects without gastric malignancies on upper gastro-duodenal endoscopy. Of 708 controls, 409 were classified into two groups histologically: 99 cases with and 310 cases without gastric mucosal atrophy. Overall, homozygosity for the DNMT3A rs6733868 minor allele was significantly associated with a reduced risk of gastric cancer (odds ratio [OR], 0.621; 95% confidence interval [CI], 0.402-0.958; P=0.031), especially of the intestinal type (OR, 0.494; 95% CI, 0.274-0.890; P=0.019). In subjects >60 years, rs6733868 minor allele homozygosity was significantly associated with gastric cancer susceptibility. Carriers of the rs6733868 minor allele had a reduced risk of severe gastric mucosal atrophy (OR, 0.495; 95% CI, 0.299-0.826; P=0.0069). In addition, the number of minor alleles of both rs6733868 and rs13428812 was significantly correlated with the risk of Helicobacter pylori (HP) infection (P=0.0070 and P=0.0050, respectively). However, rs13428812 was not associated with severe gastric mucosal atrophy or gastric carcinogenesis. The present results suggest that DNMT3A polymorphisms serve roles in the progression from HP infection to gastric mucosal atrophy and gastric carcinogenesis in terms of degree and manner.

AB - The aim of the present study was to investigate whether single nucleotide polymorphisms in the DNMT3A gene are associated with susceptibility to gastric cancer in the Japanese population. The present case-control study examined the associations between single nucleotide polymorphisms (rs6733868 and rs13428812) in DNMT3A and cancer susceptibility in 343 patients with gastric cancer and 708 subjects without gastric malignancies on upper gastro-duodenal endoscopy. Of 708 controls, 409 were classified into two groups histologically: 99 cases with and 310 cases without gastric mucosal atrophy. Overall, homozygosity for the DNMT3A rs6733868 minor allele was significantly associated with a reduced risk of gastric cancer (odds ratio [OR], 0.621; 95% confidence interval [CI], 0.402-0.958; P=0.031), especially of the intestinal type (OR, 0.494; 95% CI, 0.274-0.890; P=0.019). In subjects >60 years, rs6733868 minor allele homozygosity was significantly associated with gastric cancer susceptibility. Carriers of the rs6733868 minor allele had a reduced risk of severe gastric mucosal atrophy (OR, 0.495; 95% CI, 0.299-0.826; P=0.0069). In addition, the number of minor alleles of both rs6733868 and rs13428812 was significantly correlated with the risk of Helicobacter pylori (HP) infection (P=0.0070 and P=0.0050, respectively). However, rs13428812 was not associated with severe gastric mucosal atrophy or gastric carcinogenesis. The present results suggest that DNMT3A polymorphisms serve roles in the progression from HP infection to gastric mucosal atrophy and gastric carcinogenesis in terms of degree and manner.

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DO - 10.3892/ol.2019.9948

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