Association of genetic polymorphisms in IL17A and IL17F with gastro-duodenal diseases

Ranji Hayashi, Tomomitsu Tahara, Hisakazu Shiroeda, Yasuhiro Matsue, Takahiro Minato, Tomoe Nomura, Hideto Yamada, Takashi Saito, Kazuhiro Matsunaga, Tomoki Fukuyama, Nobuhiko Hayashi, Toshimi Otsuka, Atsushi Fukumura, Masakastu Nakamura, Mikihiro Tsutsumi, Tomoyuki Shibata, Tomiyasu Arisawa

研究成果: Article

19 引用 (Scopus)

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Background & Aim: The important role of IL-17 in inflammatory response to Helicobacter pylori (H. pylori) colonization has been indicated. We investigated the associations between gastro-duodenal diseases and polymorphisms of IL17A (rs2275913 G>A) and IL17F (rs763780 T>C). Methods: The study was performed in 548 subjects (363 controls and 185 peptic ulcer cases). The multiplex PCR-SSCP method was used to detect gene polymorphisms. Results: Overall, number of rs2275913 A allele was significantly associated with an increased risk for peptic ulcer (OR, 1.50; 95%CI, 1.11-2.01; p=0.0082). The frequency of rs2275913 GA+AA genotype was also significantly higher in ulcer cases than controls (OR, 1.72; 95%CI, 1.09-2.72; p=0.020). The rs2275913 GA+AA genotype conferred an increased risk for the severity of gastric mucosal atrophy in subjects younger than 60 years (OR, 2.83; 95%CI, 1.14-7.04; p=0.025). Both atrophy and metaplasia were increased with age in rs2275913 GA+AA genotype. In NSAIDs/aspirin users, number of rs2275913 A allele was associated with an increased risk for a peptic ulcer (OR, 3.98; 95%CI, 1.48-10.7; p=0.0061). There was no association of rs763780 with the development of peptic ulcer. Conclusions: Our results provide the evidence that rs2275913 is associated with an increased risk for peptic ulcer and the severity of the gastric mucosal atrophy in comparatively younger subjects. In addition, this allele is also associated with the increased risk for peptic ulcer in NSAIDs/aspirin users.

元の言語English
ページ(範囲)243-249
ページ数7
ジャーナルJournal of Gastrointestinal and Liver Diseases
21
発行部数3
出版物ステータスPublished - 01-09-2012

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All Science Journal Classification (ASJC) codes

  • Gastroenterology

これを引用

Hayashi, R., Tahara, T., Shiroeda, H., Matsue, Y., Minato, T., Nomura, T., Yamada, H., Saito, T., Matsunaga, K., Fukuyama, T., Hayashi, N., Otsuka, T., Fukumura, A., Nakamura, M., Tsutsumi, M., Shibata, T., & Arisawa, T. (2012). Association of genetic polymorphisms in IL17A and IL17F with gastro-duodenal diseases. Journal of Gastrointestinal and Liver Diseases, 21(3), 243-249.