Association of high-density lipoprotein cholesterol concentration with different types of stroke and coronary heart disease: The Japan Public Health Center-based prospective (JPHC) study

Isao Saito, Kazumasa Yamagishi, Yoshihiro Kokubo, Hiroshi Yatsuya, Hiroyasu Iso, Norie Sawada, Manami Inoue, Shoichiro Tsugane

研究成果: Article

7 引用 (Scopus)

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Background and aims Although low high-density lipoprotein (HDL) cholesterol concentration is an established risk factor for coronary heart disease (CHD), information regarding subtypes of stroke is very limited, especially in Asian populations. Methods A prospective study was conducted among 30,736 individuals aged 40–69 years, who lived in nine communities in Japan and did not have a history of cardiovascular disease (CVD). CHD and stroke, including its subtypes, were assessed, and sex-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for outcomes were estimated according to quintiles of HDL cholesterol using Cox proportional models adjusted for other CVD risk factors. Results We identified 296 CHD and 1712 stroke events over a median 15 yr of follow-up. HDL cholesterol concentration showed an inverse association with CHD in men and women. A low HDL cholesterol concentration slightly raised the risk for total strokes in men, but not in women. When analyzed by subtypes, we observed an inverse relationship between HDL cholesterol concentration and the incidence of lacunar infarction, with an adjusted HR for the lowest quintile of HDL cholesterol concentration compared with the highest quintile of 1.63 (95% CI, 1.00–2.66) in men and 1.97 (95% CI, 1.19–3.26) in women. HDL cholesterol concentration was positively associated with the risk of intracerebral hemorrhage (ICH) in a linear manner in women (p for trend = 0.028), but not in men. Conclusions The associations of HDL cholesterol concentration with lacunar infarction and ICH may be related to different functional properties of HDL rather than to its protective function against lipid-rich atherosclerosis.

元の言語English
ページ(範囲)147-154
ページ数8
ジャーナルAtherosclerosis
265
DOI
出版物ステータスPublished - 01-10-2017

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HDL Cholesterol
Coronary Disease
Japan
Public Health
Stroke
Prospective Studies
Lacunar Stroke
Cerebral Hemorrhage
Confidence Intervals
LDL Cholesterol
Cardiovascular Diseases
HDL Lipoproteins
Proportional Hazards Models
Atherosclerosis
Lipids
Incidence
Population

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

これを引用

Saito, Isao ; Yamagishi, Kazumasa ; Kokubo, Yoshihiro ; Yatsuya, Hiroshi ; Iso, Hiroyasu ; Sawada, Norie ; Inoue, Manami ; Tsugane, Shoichiro. / Association of high-density lipoprotein cholesterol concentration with different types of stroke and coronary heart disease : The Japan Public Health Center-based prospective (JPHC) study. :: Atherosclerosis. 2017 ; 巻 265. pp. 147-154.
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abstract = "Background and aims Although low high-density lipoprotein (HDL) cholesterol concentration is an established risk factor for coronary heart disease (CHD), information regarding subtypes of stroke is very limited, especially in Asian populations. Methods A prospective study was conducted among 30,736 individuals aged 40–69 years, who lived in nine communities in Japan and did not have a history of cardiovascular disease (CVD). CHD and stroke, including its subtypes, were assessed, and sex-specific hazard ratios (HRs) and 95{\%} confidence intervals (CIs) for outcomes were estimated according to quintiles of HDL cholesterol using Cox proportional models adjusted for other CVD risk factors. Results We identified 296 CHD and 1712 stroke events over a median 15 yr of follow-up. HDL cholesterol concentration showed an inverse association with CHD in men and women. A low HDL cholesterol concentration slightly raised the risk for total strokes in men, but not in women. When analyzed by subtypes, we observed an inverse relationship between HDL cholesterol concentration and the incidence of lacunar infarction, with an adjusted HR for the lowest quintile of HDL cholesterol concentration compared with the highest quintile of 1.63 (95{\%} CI, 1.00–2.66) in men and 1.97 (95{\%} CI, 1.19–3.26) in women. HDL cholesterol concentration was positively associated with the risk of intracerebral hemorrhage (ICH) in a linear manner in women (p for trend = 0.028), but not in men. Conclusions The associations of HDL cholesterol concentration with lacunar infarction and ICH may be related to different functional properties of HDL rather than to its protective function against lipid-rich atherosclerosis.",
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Association of high-density lipoprotein cholesterol concentration with different types of stroke and coronary heart disease : The Japan Public Health Center-based prospective (JPHC) study. / Saito, Isao; Yamagishi, Kazumasa; Kokubo, Yoshihiro; Yatsuya, Hiroshi; Iso, Hiroyasu; Sawada, Norie; Inoue, Manami; Tsugane, Shoichiro.

:: Atherosclerosis, 巻 265, 01.10.2017, p. 147-154.

研究成果: Article

TY - JOUR

T1 - Association of high-density lipoprotein cholesterol concentration with different types of stroke and coronary heart disease

T2 - The Japan Public Health Center-based prospective (JPHC) study

AU - Saito, Isao

AU - Yamagishi, Kazumasa

AU - Kokubo, Yoshihiro

AU - Yatsuya, Hiroshi

AU - Iso, Hiroyasu

AU - Sawada, Norie

AU - Inoue, Manami

AU - Tsugane, Shoichiro

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Background and aims Although low high-density lipoprotein (HDL) cholesterol concentration is an established risk factor for coronary heart disease (CHD), information regarding subtypes of stroke is very limited, especially in Asian populations. Methods A prospective study was conducted among 30,736 individuals aged 40–69 years, who lived in nine communities in Japan and did not have a history of cardiovascular disease (CVD). CHD and stroke, including its subtypes, were assessed, and sex-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for outcomes were estimated according to quintiles of HDL cholesterol using Cox proportional models adjusted for other CVD risk factors. Results We identified 296 CHD and 1712 stroke events over a median 15 yr of follow-up. HDL cholesterol concentration showed an inverse association with CHD in men and women. A low HDL cholesterol concentration slightly raised the risk for total strokes in men, but not in women. When analyzed by subtypes, we observed an inverse relationship between HDL cholesterol concentration and the incidence of lacunar infarction, with an adjusted HR for the lowest quintile of HDL cholesterol concentration compared with the highest quintile of 1.63 (95% CI, 1.00–2.66) in men and 1.97 (95% CI, 1.19–3.26) in women. HDL cholesterol concentration was positively associated with the risk of intracerebral hemorrhage (ICH) in a linear manner in women (p for trend = 0.028), but not in men. Conclusions The associations of HDL cholesterol concentration with lacunar infarction and ICH may be related to different functional properties of HDL rather than to its protective function against lipid-rich atherosclerosis.

AB - Background and aims Although low high-density lipoprotein (HDL) cholesterol concentration is an established risk factor for coronary heart disease (CHD), information regarding subtypes of stroke is very limited, especially in Asian populations. Methods A prospective study was conducted among 30,736 individuals aged 40–69 years, who lived in nine communities in Japan and did not have a history of cardiovascular disease (CVD). CHD and stroke, including its subtypes, were assessed, and sex-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for outcomes were estimated according to quintiles of HDL cholesterol using Cox proportional models adjusted for other CVD risk factors. Results We identified 296 CHD and 1712 stroke events over a median 15 yr of follow-up. HDL cholesterol concentration showed an inverse association with CHD in men and women. A low HDL cholesterol concentration slightly raised the risk for total strokes in men, but not in women. When analyzed by subtypes, we observed an inverse relationship between HDL cholesterol concentration and the incidence of lacunar infarction, with an adjusted HR for the lowest quintile of HDL cholesterol concentration compared with the highest quintile of 1.63 (95% CI, 1.00–2.66) in men and 1.97 (95% CI, 1.19–3.26) in women. HDL cholesterol concentration was positively associated with the risk of intracerebral hemorrhage (ICH) in a linear manner in women (p for trend = 0.028), but not in men. Conclusions The associations of HDL cholesterol concentration with lacunar infarction and ICH may be related to different functional properties of HDL rather than to its protective function against lipid-rich atherosclerosis.

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