Association of serum oxidized lipoprotein(a) concentration with coronary artery disease: Potential role of oxidized lipoprotein(a) in the vasucular wall

Ryuichi Morishita, Junichi Ishii, Yoshiaki Kusumi, Shingo Yamada, Norio Komai, Minoru Ohishi, Masanori Nomura, Hitoshi Hishida, Mari Niihashi, Masako Mitsumata

研究成果: Article査読

23 被引用数 (Scopus)

抄録

Aim: A new antibody reacted with an epitope in Lp(a) that has undergone oxidation treatment, but is not present in native Lp(a), was developed. Thus, we determined serum oxidized Lp(a) concentration in healthy volunteers, and coronary artery disease (CAD), diabetes mellitus (DM), and hypertensive patients. Methods: We measured serum levels of oxidized Lp(a), Lp(a), LDL-cholesterol and HDL-cholesterol in 122 consecutive patients who underwent routine coronary angiography and had significant coronary artery stenosis (>75%), and 164 age-matched healthy volunteers. Moreover, serum native Lp(a), oxidized Lp(a) concentration, and pulse wave velocity (PWV) were determined in 181 hypertensive patients. Results: Oxidized Lp(a) level in CAD patients with DM was significantly higher than in healthy volunteers (p < 0.01). Moreover, serum oxidized Lp(a) concentration showed a significant positive correlation with pulse wave velocity, an index of arteriosclerosis (r = 0.431, p < 0.01). Of importance, the deposition of oxidized Lp(a) was readily detected in calcified areas of coronary arteries in patients with myocardial infarction. Conclusion: The present study demonstrated that oxidized Lp(a) may be a new risk factor for coronary artery disease. As the deposition of oxidized Lp(a) was detected in calcified areas of coronary arteries, oxidized Lp(a) might be implicated in endothelial dysfunction.

本文言語English
ページ(範囲)410-418
ページ数9
ジャーナルJournal of atherosclerosis and thrombosis
16
4
DOI
出版ステータスPublished - 2009

All Science Journal Classification (ASJC) codes

  • 内科学
  • 循環器および心血管医学
  • 生化学、医学

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