Association of serum phytoestrogen concentration and dietary habits in a sample set of the JACC Study

Kotaro Ozasa, Masahiro Nakao, Yoshiyuki Watanabe, Kyohei Hayashi, Tsuneharu Miki, Kazuya Mikami, Mitsuru Mori, Fumio Sakauchi, Masakazu Washio, Yoshinori Ito, Koji Suzuki, Tatsuhiko Kubo, Kenji Wakai, Akiko Tamakoshi, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Yutaka InabaYoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Hideaki Toyoshima, Shinkan Tokudome, Shuji Hashimoto, Shogo Kikuchi, Akio Koizumi, Takashi Kawamura, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Norihiko Hayakawa, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoro, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima

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Background: Phytoestrogens may be associated with a reduced risk of hormone dependent neoplasms such as prostate and breast cancers. We tried to determine the validity of the association between serum phytoestrogen concentrations and dietary habits obtained from a food frequency questionnaire used in the Japan Collaborative Cohort Study (JACC Study) for Evaluation of Cancer Risk sponsored by the Ministry of Education, Science, Sports and Culture of Japan (Monbusho). Methods: The subjects were 151 male controls who were selected for a nested case-control study for evaluating prostate cancer risk as part of the JACC Study. Dietary habits were determined using a food frequency questionnaire at baseline, and the concentrations of genistein, daidzein, and equol in frozen-stored serum samples assayed in 2002 were compared. Results: Tofu intake showed a significant association with the serum concentrations of genistein and daidzein (Spearman's correlation coefficients (rs) =0.30 and 0.27, respectively), and miso soup showed a slight association with serum concentrations of these phytoestrogens. In contrast, serum concentrations of equol were not associated with dietary intake of tofu and miso soup. After adjustment for serum daidzein concentration, serum equol concentration was associated with the intake of foods containing fat, meat, and coffee, but not green tea. Conclusions: Serum genistein and daidzein concentrations were significantly associated with dietary intake of tofu, and slightly with intake of miso soup. Consumption of fat, meat, and coffee may be associated with equol production by intestinal microflora in this sample set.

元の言語English
ページ(範囲)S196-S202
ジャーナルJournal of epidemiology
15
発行部数SUPPL. 2
DOI
出版物ステータスPublished - 14-10-2005

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All Science Journal Classification (ASJC) codes

  • Epidemiology

これを引用

Ozasa, K., Nakao, M., Watanabe, Y., Hayashi, K., Miki, T., Mikami, K., Mori, M., Sakauchi, F., Washio, M., Ito, Y., Suzuki, K., Kubo, T., Wakai, K., Tamakoshi, A., Motohashi, Y., Tsuji, I., Nakamura, Y., Iso, H., Mikami, H., ... Tajima, K. (2005). Association of serum phytoestrogen concentration and dietary habits in a sample set of the JACC Study. Journal of epidemiology, 15(SUPPL. 2), S196-S202. https://doi.org/10.2188/jea.15.S196