Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan

Kanako Itoh, Kenji Hashimoto, Eiji Shimizu, Yoshimoto Sekine, Norio Ozaki, Toshiya Inada, Mutsuo Harano, Nakao Iwata, Tokutaro Komiyama, Mitsuhiko Yamada, Ichiro Sora, Kenji Nakata, Hiroshi Ujike, Masaomi Iyo

研究成果: Article

43 引用 (Scopus)

抄録

Several lines of evidence suggest that genetic factors might contribute to drug abuse vulnerability. Recent genomic scans for association demonstrated that the brain-derived neurotrophic factor (BDNF) gene was associated with drug abuse vulnerability. In this study, we analyzed association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (C270T named formerly) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with methamphetamine (MAP) abuse in Japan. No significant differences were found in the frequency of the genotype or allele in these two SNPs between MAP abusers and controls (132C > T in exon V: genotype, P = 0.586, allele, P = 0.594; 196G > A (val66met) in exon XIIIA: genotype, P = 0.889, allele, P = 0.713). Furthermore, there was no difference between clinical parameters (e.g., prognosis psychosis, spontaneous relapse, or poly-substance abuse) and the two SNPs of BDNF gene. These results suggest that the two SNPs (132C > T in exon V and 196G > A (val66met) in exon XIIIA) of the BDNF gene may not be associated with Japanese MAP abusers.

元の言語English
ページ(範囲)70-73
ページ数4
ジャーナルAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
132 B
発行部数1
DOI
出版物ステータスPublished - 05-01-2005

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Methamphetamine
Brain-Derived Neurotrophic Factor
Exons
Japan
Single Nucleotide Polymorphism
Genes
Substance-Related Disorders
Alleles
Genotype
Psychotic Disorders
Recurrence

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

これを引用

Itoh, Kanako ; Hashimoto, Kenji ; Shimizu, Eiji ; Sekine, Yoshimoto ; Ozaki, Norio ; Inada, Toshiya ; Harano, Mutsuo ; Iwata, Nakao ; Komiyama, Tokutaro ; Yamada, Mitsuhiko ; Sora, Ichiro ; Nakata, Kenji ; Ujike, Hiroshi ; Iyo, Masaomi. / Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan. :: American Journal of Medical Genetics - Neuropsychiatric Genetics. 2005 ; 巻 132 B, 番号 1. pp. 70-73.
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title = "Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan",
abstract = "Several lines of evidence suggest that genetic factors might contribute to drug abuse vulnerability. Recent genomic scans for association demonstrated that the brain-derived neurotrophic factor (BDNF) gene was associated with drug abuse vulnerability. In this study, we analyzed association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (C270T named formerly) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with methamphetamine (MAP) abuse in Japan. No significant differences were found in the frequency of the genotype or allele in these two SNPs between MAP abusers and controls (132C > T in exon V: genotype, P = 0.586, allele, P = 0.594; 196G > A (val66met) in exon XIIIA: genotype, P = 0.889, allele, P = 0.713). Furthermore, there was no difference between clinical parameters (e.g., prognosis psychosis, spontaneous relapse, or poly-substance abuse) and the two SNPs of BDNF gene. These results suggest that the two SNPs (132C > T in exon V and 196G > A (val66met) in exon XIIIA) of the BDNF gene may not be associated with Japanese MAP abusers.",
author = "Kanako Itoh and Kenji Hashimoto and Eiji Shimizu and Yoshimoto Sekine and Norio Ozaki and Toshiya Inada and Mutsuo Harano and Nakao Iwata and Tokutaro Komiyama and Mitsuhiko Yamada and Ichiro Sora and Kenji Nakata and Hiroshi Ujike and Masaomi Iyo",
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Itoh, K, Hashimoto, K, Shimizu, E, Sekine, Y, Ozaki, N, Inada, T, Harano, M, Iwata, N, Komiyama, T, Yamada, M, Sora, I, Nakata, K, Ujike, H & Iyo, M 2005, 'Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan', American Journal of Medical Genetics - Neuropsychiatric Genetics, 巻. 132 B, 番号 1, pp. 70-73. https://doi.org/10.1002/ajmg.b.30097

Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan. / Itoh, Kanako; Hashimoto, Kenji; Shimizu, Eiji; Sekine, Yoshimoto; Ozaki, Norio; Inada, Toshiya; Harano, Mutsuo; Iwata, Nakao; Komiyama, Tokutaro; Yamada, Mitsuhiko; Sora, Ichiro; Nakata, Kenji; Ujike, Hiroshi; Iyo, Masaomi.

:: American Journal of Medical Genetics - Neuropsychiatric Genetics, 巻 132 B, 番号 1, 05.01.2005, p. 70-73.

研究成果: Article

TY - JOUR

T1 - Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan

AU - Itoh, Kanako

AU - Hashimoto, Kenji

AU - Shimizu, Eiji

AU - Sekine, Yoshimoto

AU - Ozaki, Norio

AU - Inada, Toshiya

AU - Harano, Mutsuo

AU - Iwata, Nakao

AU - Komiyama, Tokutaro

AU - Yamada, Mitsuhiko

AU - Sora, Ichiro

AU - Nakata, Kenji

AU - Ujike, Hiroshi

AU - Iyo, Masaomi

PY - 2005/1/5

Y1 - 2005/1/5

N2 - Several lines of evidence suggest that genetic factors might contribute to drug abuse vulnerability. Recent genomic scans for association demonstrated that the brain-derived neurotrophic factor (BDNF) gene was associated with drug abuse vulnerability. In this study, we analyzed association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (C270T named formerly) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with methamphetamine (MAP) abuse in Japan. No significant differences were found in the frequency of the genotype or allele in these two SNPs between MAP abusers and controls (132C > T in exon V: genotype, P = 0.586, allele, P = 0.594; 196G > A (val66met) in exon XIIIA: genotype, P = 0.889, allele, P = 0.713). Furthermore, there was no difference between clinical parameters (e.g., prognosis psychosis, spontaneous relapse, or poly-substance abuse) and the two SNPs of BDNF gene. These results suggest that the two SNPs (132C > T in exon V and 196G > A (val66met) in exon XIIIA) of the BDNF gene may not be associated with Japanese MAP abusers.

AB - Several lines of evidence suggest that genetic factors might contribute to drug abuse vulnerability. Recent genomic scans for association demonstrated that the brain-derived neurotrophic factor (BDNF) gene was associated with drug abuse vulnerability. In this study, we analyzed association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (C270T named formerly) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with methamphetamine (MAP) abuse in Japan. No significant differences were found in the frequency of the genotype or allele in these two SNPs between MAP abusers and controls (132C > T in exon V: genotype, P = 0.586, allele, P = 0.594; 196G > A (val66met) in exon XIIIA: genotype, P = 0.889, allele, P = 0.713). Furthermore, there was no difference between clinical parameters (e.g., prognosis psychosis, spontaneous relapse, or poly-substance abuse) and the two SNPs of BDNF gene. These results suggest that the two SNPs (132C > T in exon V and 196G > A (val66met) in exon XIIIA) of the BDNF gene may not be associated with Japanese MAP abusers.

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DO - 10.1002/ajmg.b.30097

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