Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia

Hiroki Shibata, Ayako Tani, Tomoyuki Chikuhara, Rumiko Kikuta, Mayumi Sakai, Hideaki Ninomiya, Nobutada Tashiro, Nakao Iwata, Norio Ozaki, Yasuyuki Fukumaki

研究成果: Article

40 引用 (Scopus)

抄録

Based on the hypothesis that a glutamatergic dysfunction is involved in the pathophysiology of schizophrenia, we have been conducting systematic studies on the association between glutamate receptor genes and schizophrenia. Here we report association studies of schizophrenia with polymorphisms in group III metabotropic glutamate receptor genes, GRM4 and GRM7. We selected 8 and 43 common SNPs distributed in the entire gene regions of GRM4 (> 111 kb) and GRM7 (> 900 kb), respectively. We scanned significant associations with schizophrenia using 100 case-control pairs of Japanese. We identified two neighboring SNPs (rs12491620 and rs1450099) in GRM7 showing highly significant haplotype association with schizophrenia surviving the FDR correction. We then performed additional typing of the two SNPs using the expanded sample set (404 cases and 420 controls) and confirmed the significant association with the disease. We conclude that at least one susceptibility locus for schizophrenia is located within or nearby GRM7, whereas GRM4 is unlikely to be a major susceptibility gene for schizophrenia in the Japanese population.

元の言語English
ページ(範囲)88-96
ページ数9
ジャーナルPsychiatry Research
167
発行部数1-2
DOI
出版物ステータスPublished - 15-05-2009

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Metabotropic Glutamate Receptors
Schizophrenia
Genes
Single Nucleotide Polymorphism
Glutamate Receptors
Haplotypes
Population

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

これを引用

Shibata, Hiroki ; Tani, Ayako ; Chikuhara, Tomoyuki ; Kikuta, Rumiko ; Sakai, Mayumi ; Ninomiya, Hideaki ; Tashiro, Nobutada ; Iwata, Nakao ; Ozaki, Norio ; Fukumaki, Yasuyuki. / Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia. :: Psychiatry Research. 2009 ; 巻 167, 番号 1-2. pp. 88-96.
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abstract = "Based on the hypothesis that a glutamatergic dysfunction is involved in the pathophysiology of schizophrenia, we have been conducting systematic studies on the association between glutamate receptor genes and schizophrenia. Here we report association studies of schizophrenia with polymorphisms in group III metabotropic glutamate receptor genes, GRM4 and GRM7. We selected 8 and 43 common SNPs distributed in the entire gene regions of GRM4 (> 111 kb) and GRM7 (> 900 kb), respectively. We scanned significant associations with schizophrenia using 100 case-control pairs of Japanese. We identified two neighboring SNPs (rs12491620 and rs1450099) in GRM7 showing highly significant haplotype association with schizophrenia surviving the FDR correction. We then performed additional typing of the two SNPs using the expanded sample set (404 cases and 420 controls) and confirmed the significant association with the disease. We conclude that at least one susceptibility locus for schizophrenia is located within or nearby GRM7, whereas GRM4 is unlikely to be a major susceptibility gene for schizophrenia in the Japanese population.",
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Shibata, H, Tani, A, Chikuhara, T, Kikuta, R, Sakai, M, Ninomiya, H, Tashiro, N, Iwata, N, Ozaki, N & Fukumaki, Y 2009, 'Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia', Psychiatry Research, 巻. 167, 番号 1-2, pp. 88-96. https://doi.org/10.1016/j.psychres.2007.12.002

Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia. / Shibata, Hiroki; Tani, Ayako; Chikuhara, Tomoyuki; Kikuta, Rumiko; Sakai, Mayumi; Ninomiya, Hideaki; Tashiro, Nobutada; Iwata, Nakao; Ozaki, Norio; Fukumaki, Yasuyuki.

:: Psychiatry Research, 巻 167, 番号 1-2, 15.05.2009, p. 88-96.

研究成果: Article

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AU - Shibata, Hiroki

AU - Tani, Ayako

AU - Chikuhara, Tomoyuki

AU - Kikuta, Rumiko

AU - Sakai, Mayumi

AU - Ninomiya, Hideaki

AU - Tashiro, Nobutada

AU - Iwata, Nakao

AU - Ozaki, Norio

AU - Fukumaki, Yasuyuki

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N2 - Based on the hypothesis that a glutamatergic dysfunction is involved in the pathophysiology of schizophrenia, we have been conducting systematic studies on the association between glutamate receptor genes and schizophrenia. Here we report association studies of schizophrenia with polymorphisms in group III metabotropic glutamate receptor genes, GRM4 and GRM7. We selected 8 and 43 common SNPs distributed in the entire gene regions of GRM4 (> 111 kb) and GRM7 (> 900 kb), respectively. We scanned significant associations with schizophrenia using 100 case-control pairs of Japanese. We identified two neighboring SNPs (rs12491620 and rs1450099) in GRM7 showing highly significant haplotype association with schizophrenia surviving the FDR correction. We then performed additional typing of the two SNPs using the expanded sample set (404 cases and 420 controls) and confirmed the significant association with the disease. We conclude that at least one susceptibility locus for schizophrenia is located within or nearby GRM7, whereas GRM4 is unlikely to be a major susceptibility gene for schizophrenia in the Japanese population.

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