抄録
Based on the hypothesis that a glutamatergic dysfunction is involved in the pathophysiology of schizophrenia, we have been conducting systematic studies on the association between glutamate receptor genes and schizophrenia. Here we report association studies of schizophrenia with polymorphisms in group III metabotropic glutamate receptor genes, GRM4 and GRM7. We selected 8 and 43 common SNPs distributed in the entire gene regions of GRM4 (> 111 kb) and GRM7 (> 900 kb), respectively. We scanned significant associations with schizophrenia using 100 case-control pairs of Japanese. We identified two neighboring SNPs (rs12491620 and rs1450099) in GRM7 showing highly significant haplotype association with schizophrenia surviving the FDR correction. We then performed additional typing of the two SNPs using the expanded sample set (404 cases and 420 controls) and confirmed the significant association with the disease. We conclude that at least one susceptibility locus for schizophrenia is located within or nearby GRM7, whereas GRM4 is unlikely to be a major susceptibility gene for schizophrenia in the Japanese population.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 88-96 |
| ページ数 | 9 |
| ジャーナル | Psychiatry Research |
| 巻 | 167 |
| 発行部数 | 1-2 |
| DOI | |
| 出版物ステータス | Published - 15-05-2009 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
- Biological Psychiatry
これを引用
}
Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia. / Shibata, Hiroki; Tani, Ayako; Chikuhara, Tomoyuki; Kikuta, Rumiko; Sakai, Mayumi; Ninomiya, Hideaki; Tashiro, Nobutada; Iwata, Nakao; Ozaki, Norio; Fukumaki, Yasuyuki.
：: Psychiatry Research, 巻 167, 番号 1-2, 15.05.2009, p. 88-96.研究成果: Article
TY - JOUR
T1 - Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia
AU - Shibata, Hiroki
AU - Tani, Ayako
AU - Chikuhara, Tomoyuki
AU - Kikuta, Rumiko
AU - Sakai, Mayumi
AU - Ninomiya, Hideaki
AU - Tashiro, Nobutada
AU - Iwata, Nakao
AU - Ozaki, Norio
AU - Fukumaki, Yasuyuki
PY - 2009/5/15
Y1 - 2009/5/15
N2 - Based on the hypothesis that a glutamatergic dysfunction is involved in the pathophysiology of schizophrenia, we have been conducting systematic studies on the association between glutamate receptor genes and schizophrenia. Here we report association studies of schizophrenia with polymorphisms in group III metabotropic glutamate receptor genes, GRM4 and GRM7. We selected 8 and 43 common SNPs distributed in the entire gene regions of GRM4 (> 111 kb) and GRM7 (> 900 kb), respectively. We scanned significant associations with schizophrenia using 100 case-control pairs of Japanese. We identified two neighboring SNPs (rs12491620 and rs1450099) in GRM7 showing highly significant haplotype association with schizophrenia surviving the FDR correction. We then performed additional typing of the two SNPs using the expanded sample set (404 cases and 420 controls) and confirmed the significant association with the disease. We conclude that at least one susceptibility locus for schizophrenia is located within or nearby GRM7, whereas GRM4 is unlikely to be a major susceptibility gene for schizophrenia in the Japanese population.
AB - Based on the hypothesis that a glutamatergic dysfunction is involved in the pathophysiology of schizophrenia, we have been conducting systematic studies on the association between glutamate receptor genes and schizophrenia. Here we report association studies of schizophrenia with polymorphisms in group III metabotropic glutamate receptor genes, GRM4 and GRM7. We selected 8 and 43 common SNPs distributed in the entire gene regions of GRM4 (> 111 kb) and GRM7 (> 900 kb), respectively. We scanned significant associations with schizophrenia using 100 case-control pairs of Japanese. We identified two neighboring SNPs (rs12491620 and rs1450099) in GRM7 showing highly significant haplotype association with schizophrenia surviving the FDR correction. We then performed additional typing of the two SNPs using the expanded sample set (404 cases and 420 controls) and confirmed the significant association with the disease. We conclude that at least one susceptibility locus for schizophrenia is located within or nearby GRM7, whereas GRM4 is unlikely to be a major susceptibility gene for schizophrenia in the Japanese population.
UR - http://www.scopus.com/inward/record.url?scp=64649098447&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=64649098447&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2007.12.002
DO - 10.1016/j.psychres.2007.12.002
M3 - Article
C2 - 19351574
AN - SCOPUS:64649098447
VL - 167
SP - 88
EP - 96
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 1-2
ER -