Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population: A collaborative study by the Japanese genetics initiative for drug abuse

Y. Kinoshita, M. Ikeda, H. Ujike, T. Kitajima, Y. Yamanouchi, B. Aleksic, T. Kishi, K. Kawashima, T. Ohkouchi, N. Ozaki, T. Inada, M. Harano, T. Komiyama, T. Hori, M. Yamada, Y. Sekine, M. Iyo, I. Sora, N. Iwata

研究成果: Conference contribution

6 引用 (Scopus)

抜粋

Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population.

元の言語English
ホスト出版物のタイトルDrug Addiction
ホスト出版物のサブタイトルResearch Frontiers and Treatment Advances
出版者Blackwell Publishing Inc.
ページ57-62
ページ数6
ISBN(印刷物)9781573317184
DOI
出版物ステータスPublished - 10-2008

出版物シリーズ

名前Annals of the New York Academy of Sciences
1139
ISSN(印刷物)0077-8923
ISSN(電子版)1749-6632

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

これを引用

Kinoshita, Y., Ikeda, M., Ujike, H., Kitajima, T., Yamanouchi, Y., Aleksic, B., Kishi, T., Kawashima, K., Ohkouchi, T., Ozaki, N., Inada, T., Harano, M., Komiyama, T., Hori, T., Yamada, M., Sekine, Y., Iyo, M., Sora, I., & Iwata, N. (2008). Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population: A collaborative study by the Japanese genetics initiative for drug abuse. : Drug Addiction: Research Frontiers and Treatment Advances (pp. 57-62). (Annals of the New York Academy of Sciences; 巻数 1139). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1432.021