TY - JOUR
T1 - Association study of the G72 gene with schizophrenia in a Japanese population
T2 - A multicenter study
AU - Ohi, Kazutaka
AU - Hashimoto, Ryota
AU - Yasuda, Yuka
AU - Yoshida, Tetsuhiko
AU - Takahashi, Hidetoshi
AU - Iike, Naomi
AU - Fukumoto, Motoyuki
AU - Takamura, Hironori
AU - Iwase, Masao
AU - Kamino, Kouzin
AU - Ishii, Ryouhei
AU - Kazui, Hiroaki
AU - Sekiyama, Ryuji
AU - Kitamura, Yuri
AU - Azechi, Michiyo
AU - Ikezawa, Koji
AU - Kurimoto, Ryu
AU - Kamagata, Eiichiro
AU - Tanimukai, Hitoshi
AU - Tagami, Shinji
AU - Morihara, Takashi
AU - Ogasawara, Masayuki
AU - Okochi, Masayasu
AU - Tokunaga, Hiromasa
AU - Numata, Shusuke
AU - Ikeda, Masashi
AU - Ohnuma, Tohru
AU - Ueno, Shu ichi
AU - Fukunaga, Tomoko
AU - Tanaka, Toshihisa
AU - Kudo, Takashi
AU - Arai, Heii
AU - Ohmori, Tetsuro
AU - Iwata, Nakao
AU - Ozaki, Norio
AU - Takeda, Masatoshi
N1 - Funding Information:
This work was supported in part by Grants-in-Aid from the Japanese Ministry of Health, Labor and Welfare (H18-kokoro-005, H19-kokoro-002), the Japanese Ministry of Education, Culture, Sports, Science and Technology (18689030), CREST of JST, Grant-aid for Scientific Research on Priority Areas — Research on Pathomechanisms of Brain Disorders — from the MEXT (18023045) and Japan Foundation for Neuroscience and Mental Health. The study sponsors had no further role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
PY - 2009/4
Y1 - 2009/4
N2 - G72 is one of the most widely tested genes for association with schizophrenia. As G72 activates the D-amino acid oxidase (DAO), G72 is termed D-amino acid oxidase activator (DAOA). The aim of this study is to investigate the association between G72 and schizophrenia in a Japanese population, using the largest sample size to date (1774 patients with schizophrenia and 2092 healthy controls). We examined eight single nucleotide polymorphisms (SNPs), which had been associated with schizophrenia in previous studies. We found nominal evidence for association of alleles, M22/rs778293, M23/rs3918342 and M24/rs1421292, and the genotype of M22/rs778293 with schizophrenia, although there was no association of allele or genotype in the other five SNPs. We also found nominal haplotypic association, including M15/rs2391191 and M19/rs778294 with schizophrenia. However, these associations were no longer positive after correction for multiple testing. We conclude that G72 might not play a major role in the risk for schizophrenia in the Japanese population.
AB - G72 is one of the most widely tested genes for association with schizophrenia. As G72 activates the D-amino acid oxidase (DAO), G72 is termed D-amino acid oxidase activator (DAOA). The aim of this study is to investigate the association between G72 and schizophrenia in a Japanese population, using the largest sample size to date (1774 patients with schizophrenia and 2092 healthy controls). We examined eight single nucleotide polymorphisms (SNPs), which had been associated with schizophrenia in previous studies. We found nominal evidence for association of alleles, M22/rs778293, M23/rs3918342 and M24/rs1421292, and the genotype of M22/rs778293 with schizophrenia, although there was no association of allele or genotype in the other five SNPs. We also found nominal haplotypic association, including M15/rs2391191 and M19/rs778294 with schizophrenia. However, these associations were no longer positive after correction for multiple testing. We conclude that G72 might not play a major role in the risk for schizophrenia in the Japanese population.
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U2 - 10.1016/j.schres.2009.01.019
DO - 10.1016/j.schres.2009.01.019
M3 - Article
C2 - 19237267
AN - SCOPUS:62649114005
SN - 0920-9964
VL - 109
SP - 80
EP - 85
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -
