Association study of the tumor necrosis factor-α gene and its 1A receptor gene with methamphetamine dependence

A. Nomura, Hiroshi Ujike, Y. Tanaka, M. Kishimoto, K. Otani, Y. Morita, A. Morio, M. Harano, T. Inada, M. Yamada, T. Komiyama, T. Hori, Y. Sekine, N. Iwata, I. Sora, M. Iyo, N. Ozaki, S. Kuroda

研究成果: Conference contribution

5 被引用数 (Scopus)

抄録

Recent preclinical findings that repeated treatment with methamphetamine (METH) induced an increase in tumor necrosis factor-α (TNF-α) mRNA in some brain regions and that TNF-α blocked METH neurotoxicity and rewarding effects suggest TNF-α, a multifunctional pro-inflammatory cytokine, may be involved in METH dependence. We hypothesized that genetic polymorphisms of the TNF-α gene and its receptor genes may be associated with vulnerability to METH dependence. Genetic association of -308G>A and -857C>T in the promotor region of the TNF-α gene, and 36A>G in exon 1 of the TNF receptor 1A gene (TNFR-SF1A), were analyzed in patients with METH dependence (n = 185) and healthy controls (n = 221) in a Japanese population. No significant association of alleles or haplotypes of the TNF-α or TNFR-SF1A genes with METH dependence was found. Neither was any significant association of clinical phenotype with METH dependence found. These results suggest that genetic variations in the TNF-α gene and its receptor genes may not be involved in individual vulnerability to METH dependence.

本文言語English
ホスト出版物のタイトルCellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity
ホスト出版物のサブタイトルCocaine, GHB, and Substituted Amphetamines
出版社Blackwell Publishing Inc.
ページ116-124
ページ数9
ISBN(印刷版)1573316296, 9781573316293
DOI
出版ステータスPublished - 08-2006

出版物シリーズ

名前Annals of the New York Academy of Sciences
1074
ISSN(印刷版)0077-8923
ISSN(電子版)1749-6632

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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