Associations of body mass index, smoking, and alcohol consumption with prostate cancer mortality in the Asia cohort consortium

Jay H. Fowke, Dale F. McLerran, Prakash C. Gupta, Jiang He, Xiao Ou Shu, Kunnambath Ramadas, Shoichiro Tsugane, Manami Inoue, Akiko Tamakoshi, Woon Puay Koh, Yoshikazu Nishino, Ichiro Tsuji, Kotaro Ozasa, Jian Min Yuan, Hideo Tanaka, Yoon Ok Ahn, Chien Jen Chen, Yumi Sugawara, Keun Young Yoo, Habibul AhsanWen Harn Pan, Mangesh Pednekar, Dongfeng Gu, Yong Bing Xiang, Catherine Sauvaget, Norie Sawada, Renwei Wang, Masako Kakizaki, Yasutake Tomata, Waka Ohishi, Lesley M. Butler, Isao Oze, Dong Hyun Kim, San Lin You, Sue K. Park, Faruque Parvez, Shao Yuan Chuang, Yu Chen, Jung Eun Lee, Eric Grant, Betsy Rolland, Mark Thornquist, Ziding Feng, Wei Zheng, Paolo Boffetta, Rashmi Sinha, Daehee Kang, John D. Potter

研究成果: Article

27 引用 (Scopus)

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Many potentially modifiable risk factors for prostate cancer are also associated with prostate cancer screening, which may induce a bias in epidemiologic studies. We investigated the associations of body mass index (weight (kg)/height (m)2), smoking, and alcohol consumption with risk of fatal prostate cancer in Asian countries where prostate cancer screening is not widely utilized. Analysis included 18 prospective cohort studies conducted during 1963-2006 across 6 countries in southern and eastern Asia that are part of the Asia Cohort Consortium. Body mass index, smoking, and alcohol intake were determined by questionnaire at baseline, and cause of death was ascertained through death certificates. Analysis included 522,736 men aged 54 years, on average, at baseline. During 4.8 million person-years of follow-up, there were 634 prostate cancer deaths (367 prostate cancer deaths across the 11 cohorts with alcohol data). In Cox proportional hazards analyses of all cohorts in the Asia Cohort Consortium, prostate cancer mortality was not significantly associated with obesity (body mass index >25: hazard ratio (HR) = 1.08, 95% confidence interval (CI): 0.85, 1.36), ever smoking (HR = 1.00, 95% CI: 0.84, 1.21), or heavy alcohol intake (HR = 1.00, 95% CI: 0.74, 1.35). Differences in prostate cancer screening and detection probably contribute to differences in the association of obesity, smoking, or alcohol intake with prostate cancer risk and mortality between Asian and Western populations and thus require further investigation.

元の言語English
ページ(範囲)381-389
ページ数9
ジャーナルAmerican Journal of Epidemiology
182
発行部数5
DOI
出版物ステータスPublished - 01-09-2015

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Epidemiology

これを引用

Fowke, J. H., McLerran, D. F., Gupta, P. C., He, J., Shu, X. O., Ramadas, K., Tsugane, S., Inoue, M., Tamakoshi, A., Koh, W. P., Nishino, Y., Tsuji, I., Ozasa, K., Yuan, J. M., Tanaka, H., Ahn, Y. O., Chen, C. J., Sugawara, Y., Yoo, K. Y., ... Potter, J. D. (2015). Associations of body mass index, smoking, and alcohol consumption with prostate cancer mortality in the Asia cohort consortium. American Journal of Epidemiology, 182(5), 381-389. https://doi.org/10.1093/aje/kwv089