Associations of childhood experiences with event-related potentials in adults with autism spectrum disorder

Kosuke Okazaki, Toyosaku Ota, Manabu Makinodan, Naoko Kishimoto, Kazuhiko Yamamuro, Rio Ishida, Masato Takahashi, Yuka Yasuda, Ryota Hashimoto, Junzo Iida, Toshifumi Kishimoto

研究成果: ジャーナルへの寄稿学術論文査読

12 被引用数 (Scopus)

抄録

Childhood maltreatment is defined as experiencing of physical, emotional and sexual abuse and neglect in childhood. Maltreatment in childhood leads to substantial psychosocial problems later in life in the general population. Individuals with autism spectrum disorder (ASD) have a higher risk of experiencing stressful and traumatic events, such as maltreatment, during childhood. Although childhood maltreatment reportedly leads to psychosocial problems in adults with ASD, the biological associations between childhood experiences and brain function in this population remain understudied. Here, we evaluated the relationships between childhood experiences and event-related potential (ERP) components during the auditory odd-ball task in adults with ASD (N = 21) and typically developed (TD) individuals (N = 22). We found that the higher the severity of sexual abuse, the larger the amplitude of P300 at Fz, Cz, C3, and C4 in individuals with ASD. Conversely, the severity of child maltreatment was associated with P300 latency at Cz and C3 in TD individuals. Moreover, full IQ was significantly associated with the MMN amplitude at Fz, Cz, C3, and C4 in TD individuals. These findings provide the first evidence that ERPs could be used to study the impacts childhood experiences on the brain of individuals with ASD and that childhood sexual abuse has salient impacts on brain function in this population.

本文言語英語
論文番号13447
ジャーナルScientific reports
10
1
DOI
出版ステータス出版済み - 01-12-2020
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All Science Journal Classification (ASJC) codes

  • 一般

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