TY - JOUR
T1 - Asymmetric efficacy of VNS within a single patient with bilateral focal frontal lobe epilepsy
T2 - A case report
AU - Kumon, Masanobu
AU - Nakae, Shunsuke
AU - Kojima, Daijiro
AU - Kawase, Noeru
AU - Hirose, Yuichi
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/12
Y1 - 2025/12
N2 - The lateralized efficacy of vagus nerve stimulation (VNS) remains insufficiently explored. We report a case of drug-resistant epilepsy with bilateral frontal lobe seizure onset, treated with left cervical VNS. Preoperative video- electroencephalogram revealed predominant interictal discharges in the right hemisphere and frequent seizures from both hemispheres. Following VNS, overall seizure frequency decreased. Notably, stereo-electroencephalography performed 15 months postoperatively showed a marked reduction in right-sided seizures, while left-sided seizures remained frequent. This case highlights the potential lateralized effect of VNS in a single patient with bilateral frontal lobe epilepsy, suggesting that VNS may preferentially suppress seizures originating from the right hemisphere.
AB - The lateralized efficacy of vagus nerve stimulation (VNS) remains insufficiently explored. We report a case of drug-resistant epilepsy with bilateral frontal lobe seizure onset, treated with left cervical VNS. Preoperative video- electroencephalogram revealed predominant interictal discharges in the right hemisphere and frequent seizures from both hemispheres. Following VNS, overall seizure frequency decreased. Notably, stereo-electroencephalography performed 15 months postoperatively showed a marked reduction in right-sided seizures, while left-sided seizures remained frequent. This case highlights the potential lateralized effect of VNS in a single patient with bilateral frontal lobe epilepsy, suggesting that VNS may preferentially suppress seizures originating from the right hemisphere.
KW - Drug-resistant epilepsy
KW - Lateralized efficacy
KW - Stereo-electroencephalography
KW - Vagus nerve stimulation
UR - https://www.scopus.com/pages/publications/105014182267
UR - https://www.scopus.com/pages/publications/105014182267#tab=citedBy
U2 - 10.1007/s00701-025-06653-x
DO - 10.1007/s00701-025-06653-x
M3 - Article
C2 - 40856832
AN - SCOPUS:105014182267
SN - 0001-6268
VL - 167
JO - Acta Neurochirurgica
JF - Acta Neurochirurgica
IS - 1
M1 - 228
ER -