Attenuation of benzodiazepine-induced passive avoidance deficit by post-training administration of muscimol: interaction with the cholinergic neuronal system

Toshitaka Nabeshima, Keiko Tohyama, Kenji Ichihara, Tsutomu Kameyama

研究成果: Article

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We examined the involvement of GABAergic neuronal systems in benzodiazepine-induced passive avoidance deficit. Chlordiazepoxide impaired the passive avoidance response dose dependently when it was given prior to training. Post-training administration of muscimol improved the performance of chlordiazepoxide-pretreated mice. The effects of muscimol were antagonized completely by the GABAA antagonist, bicuculline, and the muscarinic acetycholine receptor antaagonist, scopolamine, but not by the benzodiazepine receptor antagonist, flumazenil, when the latter was administered immediately after training. It appears from these results that the GABAergic neuronal system plays an important role in the benzodiazepine-induced passive avoidance deficit by interacting with the cholinergic neuronal system.

元の言語English
ページ(範囲)555-560
ページ数6
ジャーナルEuropean Journal of Pharmacology
182
発行部数3
DOI
出版物ステータスPublished - 17-07-1990

All Science Journal Classification (ASJC) codes

  • Pharmacology

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