Autoantibody against caspase-3, an executioner of apoptosis, in patients with systemic sclerosis

Shihoko Okazaki, Fumihide Ogawa, Yohei Iwata, Toshihide Hara, Eiji Muroi, Kazuhiro Komura, Motoi Takenaka, Kazuhiro Shimizu, Minoru Hasegawa, Manabu Fujimoto, Shinichi Sato

研究成果: Article査読

6 被引用数 (Scopus)

抄録

The objective of the study was to determine the presence or levels of antibodies (Abs) against caspase-3 and their clinical relevance in systemic sclerosis (SSc). Anti-caspase-3 Ab was examined by enzyme-linked immunosorbent assay and immunoblotting. IgG anti-caspase-3 Ab levels in SSc patients were higher than in normal controls. SSc patients positive for IgG anti-caspase-3 Ab had significantly longer disease duration, more frequent presence of decreased %VC and %DLco, and elevated levels of serum immunoglobulin and erythrocyte sedimentation rates. IgG anti-caspase-3 Ab levels correlated positively with serum IgG levels, renal vascular resistance, and serum levels of 8-isoprostane. Immunoblotting analysis confirmed the presence of anti-caspase-3 Ab in sera from SSc patients. Caspase-3 enzymatic activity was inhibited by IgG isolated from SSc sera containing IgG anti-caspase-3 Ab. These results suggest that autoantibody against caspase-3 is generated in SSc and that this Ab is related to the severity of pulmonary fibrosis, vascular damage, and inflammation.

本文言語English
ページ(範囲)871-878
ページ数8
ジャーナルRheumatology International
30
7
DOI
出版ステータスPublished - 05-2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • リウマチ学
  • 免疫アレルギー学
  • 免疫学

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