Aversive behavior induced by optogenetic inactivation of ventral tegmental area dopamine neurons is mediated by dopamine D2 receptors in the nucleus accumbens

Teruko Danjo, Kenji Yoshimi, Kazuo Funabiki, Satoshi Yawata, Shigetada Nakanishi

研究成果: Article査読

104 被引用数 (Scopus)

抄録

Contributed by Shigetada Nakanishi, March 23, 2014 (sent for review January 24, 2014) Dopamine (DA) transmission from the ventral tegmental area (VTA) is critical for controlling both rewarding and aversive behaviors. The transient silencing of DA neurons is one of the responses to aversive stimuli, but its consequences and neural mechanisms regarding aversive responses and learning have largely remained elusive. Here, we report that optogenetic inactivation of VTA DA neurons promptly down-regulated DA levels and induced upregulation of the neural activity in the nucleus accumbens (NAc) as evaluated by Fos expression. This optogenetic suppression of DA neuron firing immediately evoked aversive responses to the previously preferred dark room and led to aversive learning toward the optogenetically conditioned place. Importantly, this place aversion was abolished by knockdown of dopamine D2 receptors but not by that of D1 receptors in the NAc. Silencing of DA neurons in the VTA was thus indispensable for inducing aversive responses and learning through dopamine D2 receptors in the NAc.

本文言語English
ページ(範囲)6455-6460
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
111
17
DOI
出版ステータスPublished - 29-04-2014
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All Science Journal Classification (ASJC) codes

  • 一般

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