TY - JOUR
T1 - Axon specification in hippocampal neurons
AU - Fukata, Yuko
AU - Kimura, Toshihide
AU - Kaibuchi, Kozo
N1 - Funding Information:
Because of the limitations of space, we are not able to directly cite many contributions. The authors thank Dr Tadashi Tsumoto (Osaka University, Japan) for giving us the opportunity to write this manuscript. We also thank Dr Yasuo Ihara (Tokyo University), Dr Yoshio Goshima (Yokohama City University), Dr Taiji Kato (Nagoya City University), Dr Akihiro Iwamatsu (Kirin Brewery), Drs Yoshimitsu Kanai and Nobutaka Hirokawa (Tokyo University), Dr Naoyuki Inagaki (Nara Institute of Science and Technology), and Drs Tomohiko J. Itoh and Kazuhiro Hotani (Nagoya University) for fruitful collaborations and helpful discussions. We also thank C. Ménager, T. Nishimura, T. Shiromizu, H. Watanabe, and M. Yoshizaki and the members of our laboratory for preparing the manuscript. The original work by the authors was supported by grants-in-aid for scientific research from the Ministry of Education, Science, and Culture of Japan and by grants from Research for the Future of the Japan Society for the Promotion of Science and Kirin Brewery Company Limited.
PY - 2002
Y1 - 2002
N2 - Neurons are the most highly polarized cells, comprised of two structurally and functionally distinct parts, axons and dendrites. This asymmetry enables a vectorial flow of signaling within neurons. One of the most fundamental questions still to be answered in neuroscience is how these two specialized processes initially develop. The first manifestation of polarization occurs when one of the immature neurites acquires axonal characteristics. We review recent advances that have highlighted the involvement of several cellular events in the initial formation of the axon, including membrane traffic and cytoskeletal rearrangement. We then discuss the molecular mechanisms underlying axon formation, focusing on the Rho family small GTPases and an axon-inducing neuronal protein, CRMP-2.
AB - Neurons are the most highly polarized cells, comprised of two structurally and functionally distinct parts, axons and dendrites. This asymmetry enables a vectorial flow of signaling within neurons. One of the most fundamental questions still to be answered in neuroscience is how these two specialized processes initially develop. The first manifestation of polarization occurs when one of the immature neurites acquires axonal characteristics. We review recent advances that have highlighted the involvement of several cellular events in the initial formation of the axon, including membrane traffic and cytoskeletal rearrangement. We then discuss the molecular mechanisms underlying axon formation, focusing on the Rho family small GTPases and an axon-inducing neuronal protein, CRMP-2.
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U2 - 10.1016/S0168-0102(02)00062-7
DO - 10.1016/S0168-0102(02)00062-7
M3 - Review article
C2 - 12135774
AN - SCOPUS:0036312353
SN - 0168-0102
VL - 43
SP - 305
EP - 315
JO - Neuroscience Research
JF - Neuroscience Research
IS - 4
ER -