Axonal injury in experimental herpes simplex encephalitis

Isamu Mori, Fumi Goshima, Terukazu Mizuno, Yoshinori Imai, Shinichi Kohsaka, Hiroyasu Ito, Naoki Koide, Tomoaki Yoshida, Takashi Yokochi, Yoshinobu Kimura, Yukihiro Nishiyama

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Using β-amyloid precursor protein immunolabeling, we have detected axonal injury in experimental herpes simplex encephalitis. β-amyloid precursor protein-specific signals were found in the mouse brain as either puncta or axon-like structures. They appeared where infected neurons were undergoing apoptosis and Iba1-immunopositive microglia transformed themselves into macrophages. These results show, for the first time, that axonal injury, i.e., functional disturbance of the fast axonal transport, can take place during the course of acute viral encephalitis.

本文言語English
ページ(範囲)186-190
ページ数5
ジャーナルBrain Research
1057
1-2
DOI
出版ステータスPublished - 28-09-2005

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

フィンガープリント 「Axonal injury in experimental herpes simplex encephalitis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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