Basic and clinical studies on biapenem in surgery

Jiro Yura, Nagao Shinagawa, Shu Ishikawa, Akira Mizuno, Keiji Mashita, Hiroshi Ishihara, Masazumi Hisada, Akitoshi Ito, Keiichi Hori, Tatsuya Suzuki, Akihiko Iwai, Hiroshi Mizuno, Tetsushi Hayakawa, Seiji Maeda, Yoshitaka Shibata, Noriaki Mouri

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Basic and clinical studies of biapenem (BIPM), a newly-developed carbapenem antibiotic for parenteral use, were carried out in surgical field, and the following results were obtained. 1) Antibacterial activity: MIC50/MIC90 (μg/ml) against Staphylococcus aureus, Esherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa isolated from surgical lesions were respectively measured to be 25/50, ≤0.20/≤0.20, ≤0.20/0.39, 0.39/0.78. 2) Penetration into bile: After 300mg of BIPM was administered to one of cholelithiasis after operation by intravenous drip infusion, bile and serum levels were measured. The maximum bile and serum levels were 1.4μg/ml and 20.7μg/ml. 3) Clinical results: BIPM was administered to 28 patients with surgical infection. Clinical response was excellent in 9, good in 17, fair in 1 and poor in 1, resulting in a 92.9% efficacy rate. The bacteriological efficacy was respectively evaluated to be eradicated in 19, replaced in 2, partially eradicated in 1, and persisted in 2 cases, showing a 87.5% eradication rate. No adverse reaction was noted. Abnormal laboratory findings were recognized in 6 cases.

本文言語English
ページ(範囲)513-522
ページ数10
ジャーナルCHEMOTHERAPY
42
DOI
出版ステータスPublished - 01-01-1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学(医学)
  • 感染症
  • 薬理学
  • 創薬
  • 腫瘍学

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