Basic fibroblast growth factor increased glucocorticoid receptors in cortical neurons through MAP kinase pathway

Tadahiro Numakawa, Haruki Odaka, Naoki Adachi, Shuichi Chiba, Yoshiko Ooshima, Hitomi Matsuno, Shingo Nakajima, Aya Yoshimura, Kazuhiro Fumimoto, Yohei Hirai, Hiroshi Kunugi

研究成果: ジャーナルへの寄稿学術論文査読

9 被引用数 (Scopus)

抄録

Prolonged and intense stress chronically increases blood concentration of glucocorticoids, which in turn causes downregulation of glucocorticoid receptor (GR) in the central nervous system (CNS). This process has been suggested to be involved in the pathogenesis of major depressive disorder (MDD). Here, we found that basic fibroblast growth factor (bFGF) increased the expression of GR in the rat cerebral cortex and cultured cortical neurons and restored the reduced GR expression caused by glucocorticoid exposure. Among intracellular signaling pathways stimulated by bFGF, extracellular signal–regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway was responsible for the upregulation of GR. The bFGF-induced GR was functional as a transcription factor to enhance transcription of a target gene. Because high stress augments bFGF levels in the brain, it is likely that bFGF plays a compensating role for reduced GR expression after stress and thus should be studied as a therapeutic target for the treatment of MDD.

本文言語英語
ページ(範囲)217-224
ページ数8
ジャーナルNeurochemistry International
118
DOI
出版ステータス出版済み - 09-2018

All Science Journal Classification (ASJC) codes

  • 細胞および分子神経科学
  • 細胞生物学

フィンガープリント

「Basic fibroblast growth factor increased glucocorticoid receptors in cortical neurons through MAP kinase pathway」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル