Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction

Regardless of their primary causes, progressive renal fibrosis and tubular atrophy are the main predictors of progression to end-stage renal disease. Basigin/ CD147 is a multifunctional molecule - it induces matrix metalloproteinases and hyaluronan, for example - and has been implicated in organ fibrosis. However, the relationship between basigin and organ fibrosis has been poorly studied. We investigated basigin's role in renal fibrosis using a unilateral ureteral obstruction model. Basigin-deficient mice (Bsg ^-/-) demonstrated significantly less fibrosis after surgery than Bsg^+/+ mice. Fewer macrophages had infiltrated in Bsg^-/- kidneys. Consistent with these in vivo data, primary cultured tubular epithelial cells from Bsg^-/- mice produced less matrix metalloproteinase and exhibited less motility on stimulation with transforming growth factor β. Furthermore, Bsg^-/- embryonic fibro blasts produced less hyaluronan and α-smooth muscle actin after transforming growth factor β stimulation. Together, these results demonstrate for the first time that basigin is a key regulator of renal fibrosis. Basigin could be a candidate target molecule for the prevention of organ fibrosis.