Behavioral abnormality and pharmacologic response in social isolation-reared mice

Hiroyuki Koike, Daisuke Ibi, Hiroyuki Mizoguchi, Taku Nagai, Atsumi Nitta, Kazuhiro Takuma, Toshitaka Nabeshima, Yukio Yoneda, Kiyofumi Yamada

研究成果: Article査読

161 被引用数 (Scopus)


Social isolation (SI) rearing in rodents causes a variety of behavioral changes, including hyperlocomotion, anxiety, impulsivity, aggression, and learning and memory deficits. These behavioral abnormalities in rodents may be related to the symptoms in patients with neuropsychiatric disorders, such as attention-deficit hyperactivity disorder, obsessive-compulsive disorder, autism, schizophrenia and depression. In this study, we examined the effect of long-term SI rearing after weaning on emotional behaviors and cognitive function in mice. Furthermore, the effects of methylphenidate (MPH), clozapine (CLZ) and fluoxetine (FLX) on SI-induced behavioral changes were examined to measure the predictive validity of SI-reared mice as an animal model for these neuropsychiatric disorders. MPH improved SI-induced anxiety-like behavior in the elevated-plus maze test, but had no effect on aggressive behavior. In contrast, CLZ ameliorated aggressive behavior, but not anxiety-like behavior in SI-reared mice. Repeated FLX treatment prevented SI-induced aggressive behavior and social interaction deficits. These findings suggest that SI-induced behavioral abnormality is a psychobehavioral complex relevant to various clinical symptoms observed in neuropsychiatric disorders and that SI-reared mice are a useful animal model to study the pathophysiology/pathogenesis of these diseases.

ジャーナルBehavioural Brain Research
出版ステータスPublished - 24-08-2009

All Science Journal Classification (ASJC) codes

  • 行動神経科学


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