Behavioral phenotypes in schizophrenic animal models with multiple combinations of genetic and environmental factors

Hirotake Hida, Akihiro Mouri, Yukihiro Noda

研究成果: Review article査読

29 被引用数 (Scopus)

抄録

Schizophrenia is a multifactorial psychiatric disorder in which both genetic and environmental factors play a role. Genetic [e.g., Disrupted-in-schizophrenia 1 (DISC1), Neuregulin-1 (NRG1)] and environmental factors (e.g., maternal viral infection, obstetric complications, social stress) may act during the developmental period to increase the incidence of schizophrenia. In animal models, interactions between susceptibility genes and the environment can be controlled in ways not possible in humans; therefore, such models are useful for investigating interactions between or within factors in the pathogenesis and pathophysiology of schizophrenia. We provide an overview of schizophrenic animal models investigating interactions between or within factors. First, we reviewed gene-environment interaction animal models, in which schizophrenic candidate gene mutant mice were subjected to perinatal immune activation or adolescent stress. Next, environment-environment interaction animal models, in which mice were subjected to a combination of perinatal immune activation and adolescent administration of drugs, were described. These animal models showed interaction between or within factors; behavioral changes, which were obscured by each factor, were marked by interaction of factors and vice versa. Appropriate behavioral approaches with such models will be invaluable for translational research on novel compounds, and also for providing insight into the pathogenesis and pathophysiology of schizophrenia.

本文言語English
ページ(範囲)185-191
ページ数7
ジャーナルJournal of Pharmacological Sciences
121
3
DOI
出版ステータスPublished - 13-05-2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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