Behavioural and neurochemical features of olfactory bulbectomized rats resembling depression with comorbid anxiety

Dayong Wang, Yukihiro Noda, Hiroko Tsunekawa, Yuan Zhou, Masayuki Miyazaki, Koji Senzaki, Toshitaka Nabeshima

研究成果: Article

75 引用 (Scopus)

抄録

In order to probe the nature and validity of olfactory bulbectomized (OB) rats as a model of depression, we reevaluated their behavioural and neurochemical deficits in relation to the symptoms and neurochemical abnormalities of depression using our protocols, which distinguish anhedonia-resembling behaviour in sexual behavioural test, the hippocampus (Hip)-dependent long-term memory and anxiety-resembling behaviour specially. Besides exploratory hyperactivity in response to a novel environmental stress resembling the psychomotor agitation, OB rats showed a decrease of libido, and a deficit of long-term explicit memory, resembling loss of interest and cognitive deficits in depressive patients, respectively. OB rats also exhibited the anxiety symptom-resembling behaviour in social interaction and plus-maze tests. In the OB rats, we found degenerated neurons in the piriform cortex, decreased protein expression of NMDA receptor subunit 1 (NR1), but not NR2A or NR2B, in the prefrontal cortex (PFC), Hip and amygdala (Amg), and decreased phosphorylation of cAMP-response element-binding protein (CREB) in the PFC and Hip, but not Amg. The behavioural and neurochemical abnormalities in OB rats, except for the performance in the plus-maze task and neuronal degeneration, were significantly attenuated by repeated treatment with desipramine (10 mg/kg), a typical antidepressant. The present study indicated that OB rats may be a model of depression with comorbid anxiety, characterized by agitation, sexual and cognitive dysfunction, neuronal degeneration, decreased protein expression of NR1, and decreased phosphorylation of CREB.

元の言語English
ページ(範囲)262-273
ページ数12
ジャーナルBehavioural Brain Research
178
発行部数2
DOI
出版物ステータスPublished - 28-03-2007

Fingerprint

Anxiety
Depression
Cyclic AMP Response Element-Binding Protein
Hippocampus
Long-Term Memory
Amygdala
Prefrontal Cortex
N-Methyl-D-Aspartate Receptors
Phosphorylation
Anhedonia
Libido
Psychomotor Agitation
Desipramine
Memory Disorders
Interpersonal Relations
Sexual Behavior
Antidepressive Agents
Proteins
Neurons
Therapeutics

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

これを引用

Wang, Dayong ; Noda, Yukihiro ; Tsunekawa, Hiroko ; Zhou, Yuan ; Miyazaki, Masayuki ; Senzaki, Koji ; Nabeshima, Toshitaka. / Behavioural and neurochemical features of olfactory bulbectomized rats resembling depression with comorbid anxiety. :: Behavioural Brain Research. 2007 ; 巻 178, 番号 2. pp. 262-273.
@article{d814e3cbd39c4ca3bcd632368248bc2b,
title = "Behavioural and neurochemical features of olfactory bulbectomized rats resembling depression with comorbid anxiety",
abstract = "In order to probe the nature and validity of olfactory bulbectomized (OB) rats as a model of depression, we reevaluated their behavioural and neurochemical deficits in relation to the symptoms and neurochemical abnormalities of depression using our protocols, which distinguish anhedonia-resembling behaviour in sexual behavioural test, the hippocampus (Hip)-dependent long-term memory and anxiety-resembling behaviour specially. Besides exploratory hyperactivity in response to a novel environmental stress resembling the psychomotor agitation, OB rats showed a decrease of libido, and a deficit of long-term explicit memory, resembling loss of interest and cognitive deficits in depressive patients, respectively. OB rats also exhibited the anxiety symptom-resembling behaviour in social interaction and plus-maze tests. In the OB rats, we found degenerated neurons in the piriform cortex, decreased protein expression of NMDA receptor subunit 1 (NR1), but not NR2A or NR2B, in the prefrontal cortex (PFC), Hip and amygdala (Amg), and decreased phosphorylation of cAMP-response element-binding protein (CREB) in the PFC and Hip, but not Amg. The behavioural and neurochemical abnormalities in OB rats, except for the performance in the plus-maze task and neuronal degeneration, were significantly attenuated by repeated treatment with desipramine (10 mg/kg), a typical antidepressant. The present study indicated that OB rats may be a model of depression with comorbid anxiety, characterized by agitation, sexual and cognitive dysfunction, neuronal degeneration, decreased protein expression of NR1, and decreased phosphorylation of CREB.",
author = "Dayong Wang and Yukihiro Noda and Hiroko Tsunekawa and Yuan Zhou and Masayuki Miyazaki and Koji Senzaki and Toshitaka Nabeshima",
year = "2007",
month = "3",
day = "28",
doi = "10.1016/j.bbr.2007.01.003",
language = "English",
volume = "178",
pages = "262--273",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "2",

}

Behavioural and neurochemical features of olfactory bulbectomized rats resembling depression with comorbid anxiety. / Wang, Dayong; Noda, Yukihiro; Tsunekawa, Hiroko; Zhou, Yuan; Miyazaki, Masayuki; Senzaki, Koji; Nabeshima, Toshitaka.

:: Behavioural Brain Research, 巻 178, 番号 2, 28.03.2007, p. 262-273.

研究成果: Article

TY - JOUR

T1 - Behavioural and neurochemical features of olfactory bulbectomized rats resembling depression with comorbid anxiety

AU - Wang, Dayong

AU - Noda, Yukihiro

AU - Tsunekawa, Hiroko

AU - Zhou, Yuan

AU - Miyazaki, Masayuki

AU - Senzaki, Koji

AU - Nabeshima, Toshitaka

PY - 2007/3/28

Y1 - 2007/3/28

N2 - In order to probe the nature and validity of olfactory bulbectomized (OB) rats as a model of depression, we reevaluated their behavioural and neurochemical deficits in relation to the symptoms and neurochemical abnormalities of depression using our protocols, which distinguish anhedonia-resembling behaviour in sexual behavioural test, the hippocampus (Hip)-dependent long-term memory and anxiety-resembling behaviour specially. Besides exploratory hyperactivity in response to a novel environmental stress resembling the psychomotor agitation, OB rats showed a decrease of libido, and a deficit of long-term explicit memory, resembling loss of interest and cognitive deficits in depressive patients, respectively. OB rats also exhibited the anxiety symptom-resembling behaviour in social interaction and plus-maze tests. In the OB rats, we found degenerated neurons in the piriform cortex, decreased protein expression of NMDA receptor subunit 1 (NR1), but not NR2A or NR2B, in the prefrontal cortex (PFC), Hip and amygdala (Amg), and decreased phosphorylation of cAMP-response element-binding protein (CREB) in the PFC and Hip, but not Amg. The behavioural and neurochemical abnormalities in OB rats, except for the performance in the plus-maze task and neuronal degeneration, were significantly attenuated by repeated treatment with desipramine (10 mg/kg), a typical antidepressant. The present study indicated that OB rats may be a model of depression with comorbid anxiety, characterized by agitation, sexual and cognitive dysfunction, neuronal degeneration, decreased protein expression of NR1, and decreased phosphorylation of CREB.

AB - In order to probe the nature and validity of olfactory bulbectomized (OB) rats as a model of depression, we reevaluated their behavioural and neurochemical deficits in relation to the symptoms and neurochemical abnormalities of depression using our protocols, which distinguish anhedonia-resembling behaviour in sexual behavioural test, the hippocampus (Hip)-dependent long-term memory and anxiety-resembling behaviour specially. Besides exploratory hyperactivity in response to a novel environmental stress resembling the psychomotor agitation, OB rats showed a decrease of libido, and a deficit of long-term explicit memory, resembling loss of interest and cognitive deficits in depressive patients, respectively. OB rats also exhibited the anxiety symptom-resembling behaviour in social interaction and plus-maze tests. In the OB rats, we found degenerated neurons in the piriform cortex, decreased protein expression of NMDA receptor subunit 1 (NR1), but not NR2A or NR2B, in the prefrontal cortex (PFC), Hip and amygdala (Amg), and decreased phosphorylation of cAMP-response element-binding protein (CREB) in the PFC and Hip, but not Amg. The behavioural and neurochemical abnormalities in OB rats, except for the performance in the plus-maze task and neuronal degeneration, were significantly attenuated by repeated treatment with desipramine (10 mg/kg), a typical antidepressant. The present study indicated that OB rats may be a model of depression with comorbid anxiety, characterized by agitation, sexual and cognitive dysfunction, neuronal degeneration, decreased protein expression of NR1, and decreased phosphorylation of CREB.

UR - http://www.scopus.com/inward/record.url?scp=33847381860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847381860&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2007.01.003

DO - 10.1016/j.bbr.2007.01.003

M3 - Article

C2 - 17261334

AN - SCOPUS:33847381860

VL - 178

SP - 262

EP - 273

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 2

ER -