TY - JOUR
T1 - Bib and autoimmunity
AU - Hoshino, Kei
AU - Sugiura, Kazumitsu
AU - Tomita, Yasushi
AU - Muro, Yoshinao
PY - 2007
Y1 - 2007
N2 - Bip is a key chaperone of endoplasmic reticulum (ER) function due to its roles in protein folding and assembly, targeting misfolded protein for degradation, and controlling the activation of ER stress sensors. ER stress has been suggested to be involved in various diseases, such as diabetes, cardiovascular diseases, neurodegenerative diseases, and cancer. Recently, autoantibodies against Bip were detected in the sera from patients with prostate cancer and those with rheumatoid arthritis. In this review, we summarize recent findings concerning Bip and anti-Bip autoantibodies in cancer and autoimmune diseases.
AB - Bip is a key chaperone of endoplasmic reticulum (ER) function due to its roles in protein folding and assembly, targeting misfolded protein for degradation, and controlling the activation of ER stress sensors. ER stress has been suggested to be involved in various diseases, such as diabetes, cardiovascular diseases, neurodegenerative diseases, and cancer. Recently, autoantibodies against Bip were detected in the sera from patients with prostate cancer and those with rheumatoid arthritis. In this review, we summarize recent findings concerning Bip and anti-Bip autoantibodies in cancer and autoimmune diseases.
UR - http://www.scopus.com/inward/record.url?scp=56749142937&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56749142937&partnerID=8YFLogxK
M3 - Review article
AN - SCOPUS:56749142937
SN - 0972-4524
VL - 8
SP - 61
EP - 66
JO - Current Topics in Peptide and Protein Research
JF - Current Topics in Peptide and Protein Research
ER -
