Biliary and renal excretions of cefpiramide in eisai hyperbilirubinemic rats

I. Muraoka, T. Hasegawa, M. Nadai, L. Wang, S. Haghgoo, O. Tagaya, T. Nabeshima

研究成果: Article

10 引用 (Scopus)

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Eisai hyperbilirubinemic mutant rats (EHBRs) with conjugated hyperbilirubinemia were recently derived from Sprague-Dawley rats (SDRs). The pharmacokinetic characteristics of the β-lactam antibiotic cefpiramide (CPM), which is mainly excreted into bile, were investigated in 10- and 20- week-old EHBRs and were compared with those in 20-week-old healthy SDRs. The pharmacokinetic parameters of CPM after an intravenous administration of 20 mg/kg of body weight were estimated for each rat by noncompartmental methods. When compared with age-matched healthy SDRs, significant decreases (by approximately 30%) in the systemic clearance of CPM were observed in 20- week-old EHBRs. The biliary clearance of CPM in 20-week-old EHBRs markedly decreased to less than 10% of that in age-matched healthy SDRs, while total urinary recovery of unchanged CPM increased to threefold and renal clearance doubled. However, no significant differences in any of the pharmacokinetic parameters of CPM were observed between the two groups of EHBRs. There were no significant differences among the three groups in the steady-state volume of distribution of CPM. The present study indicates that hyperbilirubinemia induces an increase in the urinary excretion ability of CPM in return for a reduction in the biliary excretion.

元の言語English
ページ(範囲)70-74
ページ数5
ジャーナルAntimicrobial agents and chemotherapy
39
発行部数1
DOI
出版物ステータスPublished - 01-01-1995
外部発表Yes

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

これを引用

Muraoka, I., Hasegawa, T., Nadai, M., Wang, L., Haghgoo, S., Tagaya, O., & Nabeshima, T. (1995). Biliary and renal excretions of cefpiramide in eisai hyperbilirubinemic rats. Antimicrobial agents and chemotherapy, 39(1), 70-74. https://doi.org/10.1128/AAC.39.1.70