Bimodal effect of retinoic acid on melanocyte differentiation identified by time-dependent analysis

Yu Inoue, Seiji Hasegawa, Takaaki Yamada, Yasushi Date, Hiroshi Mizutani, Satoru Nakata, Kayoko Matsunaga, Hirohiko Akamatsu

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Retinoic acid (RA) is considered to control melanocytes; however, its precise mechanism remains unclear because of a bimodal effect, which promotes or inhibits melanin synthesis depending on the cell type, culture condition of melanocytes and skin conditions. In this study, we examined the effects of RA throughout each stage of differentiation of melanocytes using a mouse embryonic stem cell culture system to induce melanocytes. The results showed that RA has significantly different effects depending on the stage of differentiation of melanocytes. More specifically, RA promoted differentiation in earlier stages, wherein embryonic stem cells became melanoblasts via neural crest cells, and inhibited differentiation in later stages, wherein melanoblasts became melanocytes. It was revealed for the first time that melanocytes show markedly different reactions to RA depending on the stage of differentiation.

本文言語English
ページ(範囲)299-311
ページ数13
ジャーナルPigment Cell and Melanoma Research
25
3
DOI
出版ステータスPublished - 05-2012

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 生化学、遺伝学、分子生物学(全般)
  • 皮膚病学

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