Bioartificial nerve grafts based on absorbable guiding filament structures - Early observations

Nobuki Terada, Lars M. Bjursten, Daisuke Dohi, Göran Lundborg

研究成果: Article査読

27 被引用数 (Scopus)

抄録

Gaps 10 mm wide in the sciatic nerves of 64 rats were bridged by bioartificial nerve grafts consisting of a silicone tube containing seven longitudinally placed filaments made of non-absorbable, (polyamide [Ethilon®]) or absorbable, material (polydioxanone [PDS®], polyglactin [Vicryl®], and catgut). The purpose was to study the organisation of axonal growth inside the tube along such filaments. After two and four weeks histological techniques were used to study the contents of the tube and at four weeks immunohistological techniques were used to confirm the presence of axons distal to the tube. In all experimental groups axons had traversed the tube and reached the distal segment after four weeks. Inside the tube axons were organised in multiple minifascicles in all groups, but there were no axons growing in direct contact with the filaments. We conclude that resorbable filaments placed inside a silicone tube do not disturb axonal growth across the tube.

本文言語English
ページ(範囲)1-6
ページ数6
ジャーナルScandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
31
1
DOI
出版ステータスPublished - 1997
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学(全般)

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