Biological significance of mutant isocitrate dehydrogenase 1 and 2 in gliomagenesis

研究成果: Review article査読

10 被引用数 (Scopus)

抄録

Mutations of the isocitrate dehydrogenase (IDH) genes are considered an important event that occurs at an early stage during gliomagenesis. The mutations often occur in grade 2 or 3 gliomas and secondary glioblastomas. Most IDH mutations are associated with codon 132 and 172 in IDH1 and IDH2 in gliomas, respectively. While IDH1 and IDH2 catalyze the oxidative decarboxylation of isocitrate to form α-ketoglutarate (α-KG), IDH1 and IDH2 mutations convert α-KG to 2-hydroxyglutarate (2-HG). The accumulation of oncometabolite 2-HG is believed to lead progenitor cells into gliomas, inhibiting several α-KG-dependent enzymes, including ten-eleven translocation enzymes, histone demethylases, and prolyl hydroxylases, although the mechanisms have not been fully revealed. Herein, we review the contribution of IDH1 and IDH2 mutations to gliomagenesis.

本文言語English
ページ(範囲)170-179
ページ数10
ジャーナルneurologia medico-chirurgica
56
4
DOI
出版ステータスPublished - 15-04-2016

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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