Biopsy-Proven Fulminant Myocarditis Requiring Mechanical Circulatory Support Following COVID-19 mRNA Vaccination

Shingo Kazama; Takahiro Okumura; Yuki Kimura; Ryota Ito; Takashi Araki; Takashi Mizutani; Hideo Oishi; Tasuku Kuwayama; Hiroaki Hiraiwa; Toru Kondo; Ryota Morimoto; Tomoaki Saeki; Toyoaki Murohara

doi:10.1016/j.cjco.2022.02.004

Biopsy-Proven Fulminant Myocarditis Requiring Mechanical Circulatory Support Following COVID-19 mRNA Vaccination

Shingo Kazama
, Takahiro Okumura
, Yuki Kimura
, Ryota Ito
, Takashi Araki
, Takashi Mizutani
, Hideo Oishi
, Tasuku Kuwayama
, Hiroaki Hiraiwa
, Toru Kondo
, Ryota Morimoto
, Tomoaki Saeki
, Toyoaki Murohara

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

13 被引用数 (Scopus)

抄録

A 48-year-old woman suffered from cardiogenic shock with fulminant myocarditis following the second dose of COVID-19 vaccine (mRNA-1273). Venoarterial extracorporeal membrane oxygenation and Impella support were essential in achieving hemodynamic stability. Endomyocardial biopsy revealed lymphocytic infiltration with predominant immunostaining for CD8- and CD68-positive cells. The left ventricular ejection fraction improved significantly after treatment with mechanical circulatory support. Myocarditis following COVID-19 mRNA vaccination may also occur in middle-aged women; it may be fulminant and require mechanical circulatory support. Although our results suggest the involvement of cytotoxic T lymphocytes and macrophages, further investigation is needed before these can be established as pathogenetic mechanisms.

本文言語	英語
ページ（範囲）	501-505
ページ数	5
ジャーナル	CJC Open
巻	4
号	5
DOI	https://doi.org/10.1016/j.cjco.2022.02.004
出版ステータス	出版済み - 05-2022
外部発表	はい

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All Science Journal Classification (ASJC) codes

循環器および心血管医学

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10.1016/j.cjco.2022.02.004

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title = "Biopsy-Proven Fulminant Myocarditis Requiring Mechanical Circulatory Support Following COVID-19 mRNA Vaccination",

abstract = "A 48-year-old woman suffered from cardiogenic shock with fulminant myocarditis following the second dose of COVID-19 vaccine (mRNA-1273). Venoarterial extracorporeal membrane oxygenation and Impella support were essential in achieving hemodynamic stability. Endomyocardial biopsy revealed lymphocytic infiltration with predominant immunostaining for CD8- and CD68-positive cells. The left ventricular ejection fraction improved significantly after treatment with mechanical circulatory support. Myocarditis following COVID-19 mRNA vaccination may also occur in middle-aged women; it may be fulminant and require mechanical circulatory support. Although our results suggest the involvement of cytotoxic T lymphocytes and macrophages, further investigation is needed before these can be established as pathogenetic mechanisms.",

author = "Shingo Kazama and Takahiro Okumura and Yuki Kimura and Ryota Ito and Takashi Araki and Takashi Mizutani and Hideo Oishi and Tasuku Kuwayama and Hiroaki Hiraiwa and Toru Kondo and Ryota Morimoto and Tomoaki Saeki and Toyoaki Murohara",

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T1 - Biopsy-Proven Fulminant Myocarditis Requiring Mechanical Circulatory Support Following COVID-19 mRNA Vaccination

AU - Kazama, Shingo

AU - Okumura, Takahiro

AU - Kimura, Yuki

AU - Ito, Ryota

AU - Araki, Takashi

AU - Mizutani, Takashi

AU - Oishi, Hideo

AU - Kuwayama, Tasuku

AU - Hiraiwa, Hiroaki

AU - Kondo, Toru

AU - Morimoto, Ryota

AU - Saeki, Tomoaki

AU - Murohara, Toyoaki

PY - 2022/5

Y1 - 2022/5

N2 - A 48-year-old woman suffered from cardiogenic shock with fulminant myocarditis following the second dose of COVID-19 vaccine (mRNA-1273). Venoarterial extracorporeal membrane oxygenation and Impella support were essential in achieving hemodynamic stability. Endomyocardial biopsy revealed lymphocytic infiltration with predominant immunostaining for CD8- and CD68-positive cells. The left ventricular ejection fraction improved significantly after treatment with mechanical circulatory support. Myocarditis following COVID-19 mRNA vaccination may also occur in middle-aged women; it may be fulminant and require mechanical circulatory support. Although our results suggest the involvement of cytotoxic T lymphocytes and macrophages, further investigation is needed before these can be established as pathogenetic mechanisms.

AB - A 48-year-old woman suffered from cardiogenic shock with fulminant myocarditis following the second dose of COVID-19 vaccine (mRNA-1273). Venoarterial extracorporeal membrane oxygenation and Impella support were essential in achieving hemodynamic stability. Endomyocardial biopsy revealed lymphocytic infiltration with predominant immunostaining for CD8- and CD68-positive cells. The left ventricular ejection fraction improved significantly after treatment with mechanical circulatory support. Myocarditis following COVID-19 mRNA vaccination may also occur in middle-aged women; it may be fulminant and require mechanical circulatory support. Although our results suggest the involvement of cytotoxic T lymphocytes and macrophages, further investigation is needed before these can be established as pathogenetic mechanisms.

UR - https://www.scopus.com/pages/publications/85128185828

UR - https://www.scopus.com/pages/publications/85128185828#tab=citedBy

U2 - 10.1016/j.cjco.2022.02.004

DO - 10.1016/j.cjco.2022.02.004

M3 - Article

AN - SCOPUS:85128185828

SN - 2589-790X

VL - 4

SP - 501

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JO - CJC Open

JF - CJC Open

IS - 5

ER -

Biopsy-Proven Fulminant Myocarditis Requiring Mechanical Circulatory Support Following COVID-19 mRNA Vaccination

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UN SDG

All Science Journal Classification (ASJC) codes

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