Biopterin metabolism in patients with malignant syndrome

Hiroshi Ichinose, Tamae Ohye, Hitoshi Shinotoh, Kimihito Arai, Shunzo Yamazaki, Eiji Mizuta, Sadako Kuno, Toshiharu Nagatsu

研究成果: Article査読

1 被引用数 (Scopus)

抄録

We examined the autopsied brains of two parkinsonian patients who had malignant syndrome (MS). Neopterin and biopterin contents, and GTP cyclohydrolase I activity were measured in various region of the brain. We found relatively higher GTP cyclohydrolase I activities in the hypothalamus compared with other regions of the brain from patients with MS. This finding suggested a possible involvement of biopterin metabolism in pathophysiology of MS. This is the first report on biopterin metabolism in the brains of patients with MS.

本文言語English
ページ(範囲)11-14
ページ数4
ジャーナルParkinsonism and Related Disorders
9
SUPPL. 1
DOI
出版ステータスPublished - 04-2003

All Science Journal Classification (ASJC) codes

  • 神経学
  • 老年医学
  • 臨床神経学

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