Bioresorbable drug-eluting magnesium-alloy scaffold for treatment of coronary artery disease

Carlos M. Campos, Takashi Muramatsu, Javaid Iqbal, Ya Jun Zhang, Yoshinobu Onuma, Hector M. Garcia-Garcia, Michael Haude, Pedro A. Lemos, Boris Warnack, Patrick W. Serruys

研究成果: Review article査読

90 被引用数 (Scopus)

抄録

The introduction of metallic drug-eluting stents has reduced the risk of restenosis and widened the indications of percutaneous coronary intervention in treatment of coronary artery disease. However, this medical device can induce hypersensitive reaction that interferes with the endothelialization and healing process resulting in late persistent or acquired malapposition of the permanent metallic implant. Delayed endotheliaization and malapposition may lead to late and very late stent thrombosis. Bioresorbable scaffolds (BRS) have been introduced to potentially overcome these limitations, as they provide temporary scaffolding and then disappear, liberating the treated vessel from its cage. Magnesium is an essential mineral needed for a variety of physiological functions in the human body and its bioresorbable alloy has the strength-to-weight ratio comparable with that of strong aluminum alloys and alloy steels. The aim of this review is to present the new developments in Magnesium BRS technology, to describe its clinical application and to discuss the future prospects of this innovative therapy.

本文言語English
ページ(範囲)24492-24500
ページ数9
ジャーナルInternational journal of molecular sciences
14
12
DOI
出版ステータスPublished - 16-12-2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 触媒
  • 分子生物学
  • 分光学
  • コンピュータ サイエンスの応用
  • 物理化学および理論化学
  • 有機化学
  • 無機化学

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