Biosurfaced circuits reduces blood-foreign body surface reactions and diminishes platelet adhesion

Biosurfaced cardiopulmonary bypass (CPB) circuits (B) may reduce blood- foreign body surface reactions and decrease activation of coagulation systems compared with non-biosurfaced circuits (A). We performed an in vitro study using fresh human blood and a clinical study. CPB was performed using a roller pump for four hours in eight sets of each group. Bradykinin showed lower levels in group B (260 ± 60 ; 520 ± 120 pg/ml). Thrombin-antithrombin III complex, fibrinopeptide A, beta-thromboglobulin, complement factors (C3a, C4a) and granulocyte elastase were lower in group B. Platelet count were higher in group B (5.3 ± 1.3 ; 3.7 ± 0.8 x 10⁴). Scanning electron micrography showed less blood cellular adhesion to CPB circuit in group B. In clinical study only C3a and C4a showed significantly lower levels in group B. Biosurfaced circuit reduces blood-foreign body surface reactions and diminishes platelet adhesion to the surface of CPB circuit.