Blood cardioplegia infusion using a recirculation type circuit generates bradykinin in significant amounts during open heart surgery

Takashi Watanabe, Yoshimasa Sakai, Tsuyoshi Shimomura, Min Ho Song, Ken Miyahara, Yasushi Takagi, Yasutoshi Oohara, Yoshitaka Kawaradani, Akihiko Usui, Takashi Maseki, Kenzo Yasuura, Mitsuya Murase

研究成果: Article査読

抄録

The single pass type (SP) of blood cardioplegia is commonly used in North America during open heart surgery. However the recirculation type (RC) of blood cardioplegia is still widely used in other areas including Japan. Infusion blood cardioplegia using the latter technique often decreases the perfusion pressure. To determine the cause for this, blood levels of bradykinin (BK) were measured in cardiopulmonary bypass (CPB) and the 2 types of blood cardioplegic circuits. As the BK levels in the RC cardioplegia (>3,000 pg/ml) rose, the perfusion pressure decreased abruptly with the increase of the BK levels in the CPB circuit. With SP cardioplegia, the BK level was not increased either during cardioplegia (p < 0.009) or CPB (p < 0.009), and the perfusion pressure was not decreased (p < 0.02). We concluded that the SP circuit is superior to the RC one because of the lesser production of BK and thus lesser fluctuation of perfusion pressure.

本文言語English
ページ(範囲)1087-1090
ページ数4
ジャーナルArtificial Organs
21
10
DOI
出版ステータスPublished - 1997
外部発表はい

All Science Journal Classification (ASJC) codes

  • バイオエンジニアリング
  • 医学(その他)
  • 生体材料
  • 生体医工学

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