TY - JOUR
T1 - Boron neutron capture therapy as new treatment for clear cell sarcoma
T2 - Trial on different animal model
AU - Andoh, Tooru
AU - Fujimoto, Takuya
AU - Sudo, Tamotsu
AU - Suzuki, Minoru
AU - Sakurai, Yoshinori
AU - Sakuma, Toshiko
AU - Moritake, Hiroshi
AU - Sugimoto, Tohru
AU - Takeuchi, Tamotsu
AU - Sonobe, Hiroshi
AU - Epstein, Alan L.
AU - Fukumori, Yoshinobu
AU - Ono, Koji
AU - Ichikawa, Hideki
PY - 2014/6
Y1 - 2014/6
N2 - Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In our previous study, the tumor disappeared under boron neutron capture therapy (BNCT) on subcutaneously-transplanted CCS-bearing animals. In the present study, the tumor disappeared under this therapy on model mice intramuscularly implanted with three different human CCS cells. BNCT led to the suppression of tumor-growth in each of the different model mice, suggesting its potentiality as an alternative to, or integrative option for, the treatment of CCS.
AB - Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In our previous study, the tumor disappeared under boron neutron capture therapy (BNCT) on subcutaneously-transplanted CCS-bearing animals. In the present study, the tumor disappeared under this therapy on model mice intramuscularly implanted with three different human CCS cells. BNCT led to the suppression of tumor-growth in each of the different model mice, suggesting its potentiality as an alternative to, or integrative option for, the treatment of CCS.
KW - Biodistribution
KW - Boron neutron capture therapy (BNCT)
KW - Clear cell sarcoma (CCS)
KW - Neutron irradiation
KW - P-Borono-l-phenylalanine (l-BPA)
UR - https://www.scopus.com/pages/publications/84901925151
UR - https://www.scopus.com/pages/publications/84901925151#tab=citedBy
U2 - 10.1016/j.apradiso.2013.12.007
DO - 10.1016/j.apradiso.2013.12.007
M3 - Article
C2 - 24389062
AN - SCOPUS:84901925151
SN - 0969-8043
VL - 88
SP - 59
EP - 63
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
ER -