Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS

Tooru Andoh; Takuya Fujimoto; Minoru Suzuki; Tamotsu Sudo; Yoshinori Sakurai; Hiroki Tanaka; Ikuo Fujita; Naomasa Fukase; Hiroshi Moritake; Tohru Sugimoto; Toshiko Sakuma; Hiroshi Sasai; Teruya Kawamoto; Mitsunori Kirihata; Yoshinobu Fukumori; Toshihiro Akisue; Koji Ono; Hideki Ichikawa

doi:10.1016/j.apradiso.2015.07.060

Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS

Tooru Andoh
, Takuya Fujimoto
, Minoru Suzuki
, Tamotsu Sudo
, Yoshinori Sakurai
, Hiroki Tanaka
, Ikuo Fujita
, Naomasa Fukase
, Hiroshi Moritake
, Tohru Sugimoto
, Toshiko Sakuma
, Hiroshi Sasai
, Teruya Kawamoto
, Mitsunori Kirihata
, Yoshinobu Fukumori
, Toshihiro Akisue
, Koji Ono
, Hideki Ichikawa

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

18 被引用数 (Scopus)

抄録

Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In the present study, we established a lung metastasis animal model of CCS and investigated the therapeutic effect of boron neutron capture therapy (BNCT) using p-borono-l-phenylalanine (l-BPA). Biodistribution data revealed tumor-selective accumulation of ¹⁰B. Unlike conventional gamma-ray irradiation, BNCT significantly suppressed tumor growth without damaging normal tissues, suggesting that it may be a potential new therapeutic option to treat CCS lung metastases.

本文言語	英語
ページ（範囲）	195-201
ページ数	7
ジャーナル	Applied Radiation and Isotopes
巻	106
DOI	https://doi.org/10.1016/j.apradiso.2015.07.060
出版ステータス	出版済み - 01-12-2015
外部発表	はい

All Science Journal Classification (ASJC) codes

放射線

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10.1016/j.apradiso.2015.07.060

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引用スタイル

Andoh, T., Fujimoto, T., Suzuki, M., Sudo, T., Sakurai, Y., Tanaka, H., Fujita, I., Fukase, N., Moritake, H., Sugimoto, T., Sakuma, T., Sasai, H., Kawamoto, T., Kirihata, M., Fukumori, Y., Akisue, T., Ono, K., & Ichikawa, H. (2015). Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS. Applied Radiation and Isotopes, 106, 195-201. https://doi.org/10.1016/j.apradiso.2015.07.060

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title = "Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS",

abstract = "Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In the present study, we established a lung metastasis animal model of CCS and investigated the therapeutic effect of boron neutron capture therapy (BNCT) using p-borono-l-phenylalanine (l-BPA). Biodistribution data revealed tumor-selective accumulation of 10B. Unlike conventional gamma-ray irradiation, BNCT significantly suppressed tumor growth without damaging normal tissues, suggesting that it may be a potential new therapeutic option to treat CCS lung metastases.",

author = "Tooru Andoh and Takuya Fujimoto and Minoru Suzuki and Tamotsu Sudo and Yoshinori Sakurai and Hiroki Tanaka and Ikuo Fujita and Naomasa Fukase and Hiroshi Moritake and Tohru Sugimoto and Toshiko Sakuma and Hiroshi Sasai and Teruya Kawamoto and Mitsunori Kirihata and Yoshinobu Fukumori and Toshihiro Akisue and Koji Ono and Hideki Ichikawa",

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Andoh, T, Fujimoto, T, Suzuki, M, Sudo, T, Sakurai, Y, Tanaka, H, Fujita, I, Fukase, N, Moritake, H, Sugimoto, T, Sakuma, T, Sasai, H, Kawamoto, T, Kirihata, M, Fukumori, Y, Akisue, T, Ono, K & Ichikawa, H 2015, 'Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS', Applied Radiation and Isotopes, vol. 106, pp. 195-201. https://doi.org/10.1016/j.apradiso.2015.07.060

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T1 - Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment

T2 - Trial using a lung metastasis model of CCS

AU - Andoh, Tooru

AU - Fujimoto, Takuya

AU - Suzuki, Minoru

AU - Sudo, Tamotsu

AU - Sakurai, Yoshinori

AU - Tanaka, Hiroki

AU - Fujita, Ikuo

AU - Fukase, Naomasa

AU - Moritake, Hiroshi

AU - Sugimoto, Tohru

AU - Sakuma, Toshiko

AU - Sasai, Hiroshi

AU - Kawamoto, Teruya

AU - Kirihata, Mitsunori

AU - Fukumori, Yoshinobu

AU - Akisue, Toshihiro

AU - Ono, Koji

AU - Ichikawa, Hideki

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In the present study, we established a lung metastasis animal model of CCS and investigated the therapeutic effect of boron neutron capture therapy (BNCT) using p-borono-l-phenylalanine (l-BPA). Biodistribution data revealed tumor-selective accumulation of 10B. Unlike conventional gamma-ray irradiation, BNCT significantly suppressed tumor growth without damaging normal tissues, suggesting that it may be a potential new therapeutic option to treat CCS lung metastases.

AB - Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In the present study, we established a lung metastasis animal model of CCS and investigated the therapeutic effect of boron neutron capture therapy (BNCT) using p-borono-l-phenylalanine (l-BPA). Biodistribution data revealed tumor-selective accumulation of 10B. Unlike conventional gamma-ray irradiation, BNCT significantly suppressed tumor growth without damaging normal tissues, suggesting that it may be a potential new therapeutic option to treat CCS lung metastases.

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