Boron neutron capture therapy for clear cell sarcoma (CCS): Biodistribution study of p-borono-l-phenylalanine in CCS-bearing animal models

T. Andoh, T. Fujimoto, T. Sudo, I. Fujita, M. Imabori, H. Moritake, T. Sugimoto, Y. Sakuma, T. Takeuchi, S. Kawabata, M. Kirihata, T. Akisue, K. Yayama, M. Kurosaka, S. Miyatake, Y. Fukumori, H. Ichikawa

研究成果: ジャーナルへの寄稿学術論文査読

17 被引用数 (Scopus)

抄録

Clear cell sarcoma (CCS) is a rare melanocytic malignant tumor with a poor prognosis. Our previous study demonstrated that in vitro cultured CCS cells have the ability to highly uptake l-BPA and thus boron neutron capture therapy could be a new option for CCS treatment. This paper proved that a remarkably high accumulation of 10B (45-74ppm) in tumor was obtained even in a CCS-bearing animal with a well-controlled biodistribution followed by intravenous administration of l-BPA-fructose complex (500mg BPA/kg).

本文言語英語
ページ(範囲)1721-1724
ページ数4
ジャーナルApplied Radiation and Isotopes
69
12
DOI
出版ステータス出版済み - 12-2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • 放射線

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