Boron neutron capture therapy for clear cell sarcoma (CCS): Biodistribution study of p-borono-l-phenylalanine in CCS-bearing animal models

T. Andoh; T. Fujimoto; T. Sudo; I. Fujita; M. Imabori; H. Moritake; T. Sugimoto; Y. Sakuma; T. Takeuchi; S. Kawabata; M. Kirihata; T. Akisue; K. Yayama; M. Kurosaka; S. Miyatake; Y. Fukumori; H. Ichikawa

doi:10.1016/j.apradiso.2011.02.005

Boron neutron capture therapy for clear cell sarcoma (CCS): Biodistribution study of p-borono-l-phenylalanine in CCS-bearing animal models

T. Andoh
, T. Fujimoto
, T. Sudo
, I. Fujita
, M. Imabori
, H. Moritake
, T. Sugimoto
, Y. Sakuma
, T. Takeuchi
, S. Kawabata
, M. Kirihata
, T. Akisue
, K. Yayama
, M. Kurosaka
, S. Miyatake
, Y. Fukumori
, H. Ichikawa

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

18 被引用数 (Scopus)

抄録

Clear cell sarcoma (CCS) is a rare melanocytic malignant tumor with a poor prognosis. Our previous study demonstrated that in vitro cultured CCS cells have the ability to highly uptake l-BPA and thus boron neutron capture therapy could be a new option for CCS treatment. This paper proved that a remarkably high accumulation of ¹⁰B (45-74ppm) in tumor was obtained even in a CCS-bearing animal with a well-controlled biodistribution followed by intravenous administration of l-BPA-fructose complex (500mg BPA/kg).

本文言語	英語
ページ（範囲）	1721-1724
ページ数	4
ジャーナル	Applied Radiation and Isotopes
巻	69
号	12
DOI	https://doi.org/10.1016/j.apradiso.2011.02.005
出版ステータス	出版済み - 12-2011
外部発表	はい

All Science Journal Classification (ASJC) codes

放射線

文献へのアクセス

10.1016/j.apradiso.2011.02.005

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引用スタイル

Andoh, T., Fujimoto, T., Sudo, T., Fujita, I., Imabori, M., Moritake, H., Sugimoto, T., Sakuma, Y., Takeuchi, T., Kawabata, S., Kirihata, M., Akisue, T., Yayama, K., Kurosaka, M., Miyatake, S., Fukumori, Y., & Ichikawa, H. (2011). Boron neutron capture therapy for clear cell sarcoma (CCS): Biodistribution study of p-borono-l-phenylalanine in CCS-bearing animal models. Applied Radiation and Isotopes, 69(12), 1721-1724. https://doi.org/10.1016/j.apradiso.2011.02.005

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title = "Boron neutron capture therapy for clear cell sarcoma (CCS): Biodistribution study of p-borono-l-phenylalanine in CCS-bearing animal models",

abstract = "Clear cell sarcoma (CCS) is a rare melanocytic malignant tumor with a poor prognosis. Our previous study demonstrated that in vitro cultured CCS cells have the ability to highly uptake l-BPA and thus boron neutron capture therapy could be a new option for CCS treatment. This paper proved that a remarkably high accumulation of 10B (45-74ppm) in tumor was obtained even in a CCS-bearing animal with a well-controlled biodistribution followed by intravenous administration of l-BPA-fructose complex (500mg BPA/kg).",

author = "T. Andoh and T. Fujimoto and T. Sudo and I. Fujita and M. Imabori and H. Moritake and T. Sugimoto and Y. Sakuma and T. Takeuchi and S. Kawabata and M. Kirihata and T. Akisue and K. Yayama and M. Kurosaka and S. Miyatake and Y. Fukumori and H. Ichikawa",

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Andoh, T, Fujimoto, T, Sudo, T, Fujita, I, Imabori, M, Moritake, H, Sugimoto, T, Sakuma, Y, Takeuchi, T, Kawabata, S, Kirihata, M, Akisue, T, Yayama, K, Kurosaka, M, Miyatake, S, Fukumori, Y & Ichikawa, H 2011, 'Boron neutron capture therapy for clear cell sarcoma (CCS): Biodistribution study of p-borono-l-phenylalanine in CCS-bearing animal models', Applied Radiation and Isotopes, vol. 69, no. 12, pp. 1721-1724. https://doi.org/10.1016/j.apradiso.2011.02.005

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T1 - Boron neutron capture therapy for clear cell sarcoma (CCS)

T2 - Biodistribution study of p-borono-l-phenylalanine in CCS-bearing animal models

AU - Andoh, T.

AU - Fujimoto, T.

AU - Sudo, T.

AU - Fujita, I.

AU - Imabori, M.

AU - Moritake, H.

AU - Sugimoto, T.

AU - Sakuma, Y.

AU - Takeuchi, T.

AU - Kawabata, S.

AU - Kirihata, M.

AU - Akisue, T.

AU - Yayama, K.

AU - Kurosaka, M.

AU - Miyatake, S.

AU - Fukumori, Y.

AU - Ichikawa, H.

PY - 2011/12

Y1 - 2011/12

N2 - Clear cell sarcoma (CCS) is a rare melanocytic malignant tumor with a poor prognosis. Our previous study demonstrated that in vitro cultured CCS cells have the ability to highly uptake l-BPA and thus boron neutron capture therapy could be a new option for CCS treatment. This paper proved that a remarkably high accumulation of 10B (45-74ppm) in tumor was obtained even in a CCS-bearing animal with a well-controlled biodistribution followed by intravenous administration of l-BPA-fructose complex (500mg BPA/kg).

AB - Clear cell sarcoma (CCS) is a rare melanocytic malignant tumor with a poor prognosis. Our previous study demonstrated that in vitro cultured CCS cells have the ability to highly uptake l-BPA and thus boron neutron capture therapy could be a new option for CCS treatment. This paper proved that a remarkably high accumulation of 10B (45-74ppm) in tumor was obtained even in a CCS-bearing animal with a well-controlled biodistribution followed by intravenous administration of l-BPA-fructose complex (500mg BPA/kg).

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